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在阿斯图里亚斯研究队列中,使用CUN-BAE指数估计身体脂肪量及按性别划分的死亡风险。

Estimation of body fat mass using the CUN-BAE index and mortality risk by sex in the Asturias Study cohort.

作者信息

Ares Blanco Jessica, Valdés Hernández Sergio, Botas Cervero Patricia, Sánchez-Ragnarsson Cecilia, Pujante Alarcón Pedro, Menéndez-Torre Edelmiro, Delgado Álvarez Elías

机构信息

Hospital Universitario Central de Asturias, Oviedo, Asturias, España; Instituto de Investigación Sanitaria del Principado de Asturias (Grupo Endocrinología, Nutrición y Obesidad), Asturias, España.

Hospital Universitario Regional de Málaga, Málaga, España.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2019 Oct;66(8):487-494. doi: 10.1016/j.endinu.2019.02.008. Epub 2019 Apr 24.

Abstract

INTRODUCTION AND OBJECTIVES

In epidemiological studies, excess body fat (BF) has been associated with cardiometabolic risk factors, some types of cancer, and other causes of death. A new anthropometric method has been defined: The CUN-BAE index (University of Navarra Clinic-Body Fat Estimator), which is based on BMI, sex, and age. BMI and CUN-BAE index were used to assess their contribution to mortality risk from any cause in the Asturias Study cohort.

MATERIAL AND METHODS

The Asturias study is a cohort study including 1.034 individuals aged 30-75years who participated in the first study phase (1998-1999). The study included a clinical survey, physical examination, and an oral glucose tolerance test. Vital status was determined in the cohort after 18years of follow-up.

RESULTS

Two hundred and four subjects died: 93 females and 111 males (16.6% and 23.5% respectively men). Baseline values of both BMI and %BF suggesting obesity (BMI>30kg/m and CUN-BAE >25% in males and >35% in females) were found in most subjects. After adjusting for T2DM, HBP, CVD, and tobacco, the risk of all-cause and cardiovascular mortality was significantly higher as CUN-BAE increased, especially in females.

CONCLUSIONS

The CUN-BAE equation is a useful tool, especially in females, to detect those who will have a greater risk of mortality, regardless of cardiovascular risk factors.

摘要

引言与目的

在流行病学研究中,体内脂肪过多与心脏代谢风险因素、某些类型的癌症及其他死亡原因相关。已定义了一种新的人体测量方法:CUN-BAE指数(纳瓦拉大学诊所-体脂估计值),该指数基于体重指数(BMI)、性别和年龄。在阿斯图里亚斯研究队列中,使用BMI和CUN-BAE指数评估它们对任何原因导致的死亡风险的影响。

材料与方法

阿斯图里亚斯研究是一项队列研究,纳入了1034名年龄在30至75岁之间、参与第一阶段研究(1998 - 1999年)的个体。该研究包括临床调查、体格检查和口服葡萄糖耐量试验。随访18年后确定队列中的生命状态。

结果

204名受试者死亡:93名女性和111名男性(男性分别为16.6%和23.5%)。大多数受试者的BMI和体脂百分比(%BF)基线值表明存在肥胖(男性BMI>30kg/m²且CUN-BAE>25%,女性>35%)。在对2型糖尿病(T2DM)、高血压(HBP)、心血管疾病(CVD)和吸烟进行校正后,随着CUN-BAE的增加,全因死亡和心血管死亡风险显著升高,尤其是在女性中。

结论

CUN-BAE方程是一种有用的工具,特别是对女性而言,可用于检测那些无论心血管风险因素如何都具有更高死亡风险的人群。

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