Alamartine Eric, Maillard Nicolas
Service de Néphrologie Dialyse Transplantation Rénale, CHU Saint Etienne, GIMAP EA3064, Université Jean Monnet, Saint Etienne Lyon, France.
Transfus Apher Sci. 2019 Jun;58(3):262-265. doi: 10.1016/j.transci.2019.04.010. Epub 2019 Apr 19.
Plasma exchange had been proposed to treat many kidney diseases. A few controlled studies, observational studies, and mechanistic evidence have specified the better indications, which are thrombotic microangiopathies, kidney transplantation and ANCA-associated vasculitides. Plasma removal can be realized by filtration, centrifugation, or immunoadsorption, with differences in efficacy, but these also impact on volume load and anticoagulation in patients with renal failure.
血浆置换已被提议用于治疗多种肾脏疾病。一些对照研究、观察性研究及机制性证据已明确了更好的适应证，即血栓性微血管病、肾移植及抗中性粒细胞胞浆抗体相关性血管炎。血浆去除可通过过滤、离心或免疫吸附实现，其疗效存在差异，但这些方法也会影响肾衰竭患者的容量负荷及抗凝情况。
