Jones D H, Lashford L S, Dicks-Mireaux C, Kemshead J T
NCI Monogr. 1987(3):125-30.
The antigen to which the monoclonal antibody UJ13A binds is expressed by normal primate brain and most tumors of neuroectodermal origin. The antibody has been used in radioimmunologic studies in patients with neuroblastoma and glioma, though the uptake of antibody into tumors is low. Animal models have been sought to allow definition of the parameters that influence tumor uptake. Animals include nude mice, in which xenografted human tumors can be studied, and marmosets, in which the primate response to exposure to murine antibodies can be investigated. This presentation reports the preliminary pharmacokinetic data from studies of mice and marmosets and compares the data with those obtained in patients.
单克隆抗体UJ13A所结合的抗原在正常灵长类动物脑以及大多数神经外胚层起源的肿瘤中表达。该抗体已用于神经母细胞瘤和胶质瘤患者的放射免疫研究，不过抗体在肿瘤中的摄取率较低。人们一直在寻找动物模型，以确定影响肿瘤摄取的参数。所使用的动物包括可用于研究异种移植人类肿瘤的裸鼠，以及可用于研究灵长类动物对接触鼠源抗体反应的狨猴。本报告介绍了对小鼠和狨猴研究获得的初步药代动力学数据，并将这些数据与在患者身上获得的数据进行了比较。
