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[细胞膜腺苷酸环化酶和鸟苷酸环化酶活性调节紊乱作为致癌作用的一个可能因素]

[Disordered regulation of cell membrane adenyl cyclase and guanyl cyclase activity as a possible factor in carcinogenesis].

作者信息

Hermann B

出版信息

Vopr Onkol. 1978;24(10):28-31.

PMID:31030
Abstract

The author suggests an interpretation of the recently recognized significant enzymatic imbalance in cancer cell as a result of the shift in the balance of cell memrane adenyl- and guanylcyclase activities in favour of the former. The alternative patterns of the development of hypothetical central and peripheral regulatory disturbances are dealt with. The prospective new therapeutic approaches offered by the pathomechanism under study are pointed out.

摘要

作者认为,癌细胞中最近被认识到的显著酶失衡,是细胞膜腺苷酸环化酶和鸟苷酸环化酶活性平衡发生变化,向有利于前者的方向转变的结果。文中探讨了假设的中枢和外周调节紊乱发展的替代模式。指出了所研究的发病机制所提供的潜在新治疗方法。

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