Hu Qiuxia, Li Bo, She Ruonan, Wu Ximei, Tan Jinhui, Hu Jianyun, Tang Qunfang
Department of Rheumatology, People's Hospital of Longhua District of Shenzhen, Shenzhen, Guangdong 518109, China. Email:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 May 10;36(5):505-507. doi: 10.3760/cma.j.issn.1003-9406.2019.05.023.
To assess the association of single nucleotide polymorphisms (SNPs) of microRNA-146a (miR-146a) with clinical features of rheumatoid arthritis (RA).
In 126 patients with RA and 102 matched healthy controls, SNPs of miR-146a rs2910164 locus were determined with a high-resolution melting method. The association of such polymorphisms with disease activity score in 28 joints (DAS28) and clinical features of RA was assessed.
The distribution of SNPs of miR-146a rs2910164 among RA patients did not differ from that of the control group. No significant association was found between miR-146a rs2910164 polymorphism with DAS28. However, RA patients with a GG genotype had a greater chance to develop extra-articular manifestations (P<0.01).
Polymorphisms of miR-146a rs2910164 locus is not an independent risk factor for RA, though its GG genotype may be associated with extra-articular manifestations of RA.
评估微小RNA-146a（miR-146a）单核苷酸多态性（SNP）与类风湿关节炎（RA）临床特征的相关性。
采用高分辨率熔解曲线法检测126例RA患者和102例匹配的健康对照者miR-146a rs2910164位点的SNP。评估此类多态性与28个关节疾病活动评分（DAS28）及RA临床特征的相关性。
RA患者中miR-146a rs2910164的SNP分布与对照组无差异。未发现miR-146a rs2910164多态性与DAS28之间存在显著相关性。然而，GG基因型的RA患者发生关节外表现的几率更高（P<0.01）。
miR-146a rs2910164位点的多态性不是RA的独立危险因素，但其GG基因型可能与RA的关节外表现有关。
