5-羟色胺作为降钙素对大鼠胃肠道和胰腺作用的介质的一种可能作用。
A possible role for 5-hydroxytryptamine as a mediator for calcitonin actions on the gastrointestinal tract and pancreas in rats.
作者信息
Nakhla A M, Latif A
出版信息
Biochem J. 1978 Oct 15;176(1):339-42. doi: 10.1042/bj1760339.
Abstract
Administration of pig calcitonin (10 M.R.C. units/kg body wt.) produced an immediate decrease in 5-hydroxytryptamine content in the antrum-duodenum region and ileum. In contrast, the hormone treatment rapidly increased the concentration of 5-hydroxytryptamine in the blood and pancreas. Serum immunoreactive gastrin did not change over a period of 3h after calcitonin administration. The results suggest that the release of 5-hydroxytryptamine probably mediates calcitonin actions on the gastrointestinal tract and pancreas.
摘要
给予猪降钙素（10个英国医学研究委员会单位/千克体重）可使胃窦-十二指肠区域和回肠中的5-羟色胺含量立即降低。相比之下，激素治疗可迅速提高血液和胰腺中5-羟色胺的浓度。降钙素给药后3小时内，血清免疫反应性胃泌素没有变化。结果表明，5-羟色胺的释放可能介导了降钙素对胃肠道和胰腺的作用。
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