一种新的用于 Merkel 细胞癌的免疫组化标志物：胰岛素瘤相关蛋白 1（INSM1）的评估。
A new immunohistochemical marker, insulinoma-associated protein 1 (INSM1), for Merkel cell carcinoma: Evaluation of 24 cases.
机构信息
Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey.
Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey.
出版信息
Ann Diagn Pathol. 2019 Jun;40:53-58. doi: 10.1016/j.anndiagpath.2019.04.002. Epub 2019 Apr 11.
Merkel cell carcinoma (MCC) is an uncommon primary neuroendocrine carcinoma of the skin. Nowadays, pathologists are required to perform immunohistochemistry to demonstrate neuroendocrine and epithelial differentiation for diagnosis of MCC. Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor expressed in tissues undergoing terminal neuroendocrine differentiation, and INSM1 immunohistochemistry is a well-validated nuclear marker of neuroendocrine differentiation. We evaluated 24 cases of MCC for the expression of INSM1 and compared it with frequently used neuroendocrine markers, Chromogranin A, Synaptophysin, and CD56. INSM1 was positive in all cases, and its expression was stronger, more extensive, clean and homogeneous compared to other markers. As a consequence, INSM1 can be used to serve as a solitary marker for neuroendocrine differentiation due to high sensitivity and specificity in MCC cases.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见的皮肤原发性神经内分泌癌。如今，病理学家需要进行免疫组织化学检测以展示神经内分泌和上皮分化，从而诊断 MCC。胰岛素瘤相关蛋白 1（Insulinoma-associated protein 1，INSM1）是一种锌指转录因子，在经历终末神经内分泌分化的组织中表达，INSM1 免疫组织化学是神经内分泌分化的一种经过充分验证的核标记物。我们评估了 24 例 MCC 中 INSM1 的表达情况，并将其与常用的神经内分泌标志物嗜铬粒蛋白 A、突触素和 CD56 进行了比较。所有病例均为 INSM1 阳性，与其他标志物相比，其表达更强、更广泛、更清晰且更均匀。因此，由于在 MCC 病例中具有高灵敏度和特异性，INSM1 可用作神经内分泌分化的单一标志物。
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