Alhasan Khalid A
Department of Pediatrics, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia.
Saudi J Kidney Dis Transpl. 2019 Mar-Apr;30(2):291-298. doi: 10.4103/1319-2442.256835.
Therapeutic plasma exchange (TPE) is a procedure that involves the removal of a large volume of plasma that is replaced with a replacement fluid, which is usually 5% albumin or fresh-frozen plasma. This therapeutic modality presents several technical challenges in children but has become increasingly used in pediatric nephrology. Owing to advances in technology, scientists have gained substantial knowledge of the molecular pathogenesis underlying many pediatric renal diseases, supporting the use of TPE in treating these disorders. This review presents a synopsis of the literature as it relates to the accepted indications for TPE in children, the technical aspects of the procedure, and the associated complications. Increased collaboration between pediatric nephrologists will hopefully allow scientists to obtain more data in children to assess the benefits of TPE in various renal disorders and improve the quality of care provided in children with renal disorders.
治疗性血浆置换（TPE）是一种移除大量血浆并用置换液替代的操作，置换液通常为5%白蛋白或新鲜冰冻血浆。这种治疗方式在儿童中存在一些技术挑战，但在儿科肾脏病学中使用越来越多。由于技术进步，科学家对许多儿科肾脏疾病的分子发病机制有了大量了解，这支持了TPE在治疗这些疾病中的应用。本综述概述了与儿童TPE公认适应症、操作技术方面及相关并发症有关的文献。儿科肾脏病学家之间加强合作有望使科学家获得更多儿童数据，以评估TPE在各种肾脏疾病中的益处，并提高为患有肾脏疾病儿童提供的护理质量。
