Guru Pramod Kumar, Vissing Megan B, Agarwal Anjali, Krishna Murli
Department of Critical Care Medicine, Mayo Clinic, Florida, USA.
Department of Dermatology, Mayo Clinic, Florida, USA.
Saudi J Kidney Dis Transpl. 2019 Mar-Apr;30(2):526-530. doi: 10.4103/1319-2442.256862.
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease that affects immunocompromised hosts. Most often the disease is reported in association with leukemia, lymphoma, and AIDS. With recent advancements in immunosuppressive medications and subsequent rise in solid organ transplantations, it is becoming more prevalent in this population. Both the diagnosis and treatment of PML remains a challenge to the transplant community. The disease remains mostly underreported and undertreated. The diagnostic uncertainty in a renal transplant patient leads us to do the brain biopsy for suspicion and confirmation of PML.
进行性多灶性白质脑病（PML）是一种罕见的脱髓鞘疾病，影响免疫功能低下的宿主。该疾病最常与白血病、淋巴瘤和艾滋病相关报道。随着免疫抑制药物的最新进展以及实体器官移植的随之增加，它在这一人群中变得越来越普遍。PML的诊断和治疗对移植界来说仍然是一个挑战。该疾病大多报告不足且治疗不足。肾移植患者的诊断不确定性促使我们对疑似PML进行脑活检以进行确诊。
