中枢6-羟多巴胺治疗的心血管效应：间接测量与直接测量的比较

Cardiovascular effects of central 6-OHDA treatment: a comparison of indirect and direct measurements.

作者信息

Van den Buuse M, Versteeg D H, De Jong W

出版信息

Physiol Behav. 1986;38(5):743-6. doi: 10.1016/0031-9384(86)90274-x.

Abstract

The effect of intracerebro-ventricular treatment with 6-hydroxydopamine on blood pressure and heart rate was studied in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto controls (WKY). When measured with the indirect tail-cuff method, the development of hypertension was found to be markedly inhibited in 6-OHDA treated SHR, while blood pressure was slightly lower in treated WKY. Heart rate was lower in both strains, although the greatest effect was found in SHR. In contrast, direct measurement via an arterial cannula indicated significantly lower blood pressure in 6-OHDA treated SHR only. Heart rate was by this method found to be not different between the SHR groups, but was increased in treated WKY. These results indicate that the mild stress of indirect blood pressure determinations has a marked influence on the results found.

摘要

研究了向自发性高血压大鼠（SHR）和血压正常的Wistar-Kyoto对照大鼠（WKY）脑室内注射6-羟基多巴胺对血压和心率的影响。采用间接尾套法测量时，发现经6-OHDA处理的SHR的高血压发展受到显著抑制，而经处理的WKY的血压略低。两种品系的心率均降低，尽管在SHR中发现的影响最大。相比之下，通过动脉插管直接测量表明，仅经6-OHDA处理的SHR血压显著降低。通过这种方法发现，SHR组之间的心率没有差异，但经处理的WKY的心率增加。这些结果表明，间接血压测定的轻微应激对所得到的结果有显著影响。