中枢注射6-羟多巴胺会影响自发性高血压大鼠的旷场探索行为和高血压的发展。

Central 6-OHDA affects both open-field exploratory behaviour and the development of hypertension in SHR.

作者信息

Van den Buuse M, Veldhuis H D, de Boer S, Versteeg D H, de Jong W

出版信息

Pharmacol Biochem Behav. 1986 Jan;24(1):15-21. doi: 10.1016/0091-3057(86)90037-7.

Abstract

To investigate the possible relation between changes in behaviour and the development of hypertension in the spontaneously hypertensive rat (SHR), the effect of intracerebroventricular (ICV) administration of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) on blood pressure and spontaneous behaviour was studied. In addition to an attenuation of the rise in blood pressure in SHR, 6-OHDA induced a marked decrease in rearing activity in the open field towards levels found in WKY. Other parameters were either not changed (stereotyped sniffing) or influenced in a comparable way in SHR and WKY (increase in locomotion). These results suggest that ICV 6-OHDA may simultaneously affect the development of hypertension and certain components of the changed behaviour of SHR. The exact relation between the two phenomena awaits further investigation.

摘要

为了研究自发性高血压大鼠（SHR）行为变化与高血压发展之间的可能关系，研究了脑室内（ICV）注射儿茶酚胺神经毒素6-羟基多巴胺（6-OHDA）对血压和自发行为的影响。除了使SHR的血压升高幅度减弱外，6-OHDA还使旷场试验中的竖毛活动显著减少，降至WKY大鼠的水平。其他参数要么没有变化（刻板嗅探），要么在SHR和WKY中受到类似影响（运动增加）。这些结果表明，脑室内注射6-OHDA可能同时影响高血压的发展以及SHR行为改变的某些成分。这两种现象之间的确切关系有待进一步研究。