Faye Pierre Antoine, Poumeaud François, Miressi Federica, Lia Anne Sophie, Demiot Claire, Magy Laurent, Favreau Frédéric, Sturtz Franck G
EA 6309, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, University of Limoges, Limoges, France.
Department of Biochemistry and Molecular Genetics, University Hospital of Limoges, Limoges, France.
Front Neurosci. 2019 Apr 12;13:348. doi: 10.3389/fnins.2019.00348. eCollection 2019.
In this review, we draw attention to the roles of calcitriol (1,25-dihydroxyvitamin D3) in the trophicity of the peripheral nervous system. Calcitriol has long been known to be crucial in phosphocalcium homeostasis. However, recent discoveries concerning its involvement in the immune system, anti-cancer defenses, and central nervous system development suggest a more pleiotropic role than previously thought. Several studies have highlighted the impact of calcitriol deficiency as a promoting factor of various central neurological diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease. Based on these findings and recent publications, a greater role for calcitriol may be envisioned in the peripheral nervous system. Indeed, calcitriol is involved in myelination, axonal homogeneity of peripheral nerves, and neuronal-cell differentiation. This may have useful clinical consequences, as calcitriol supplementation may be a simple means to avoid the onset and/or development of peripheral nervous-system disorders.
在本综述中，我们提请注意骨化三醇（1,25 - 二羟基维生素D3）在周围神经系统营养方面的作用。长期以来，人们都知道骨化三醇在磷酸钙稳态中起着关键作用。然而，最近有关其参与免疫系统、抗癌防御以及中枢神经系统发育的发现表明，它的作用比之前认为的更为多效。多项研究强调了骨化三醇缺乏作为多种中枢神经疾病（如多发性硬化症、肌萎缩侧索硬化症、帕金森病和阿尔茨海默病）的促发因素所产生的影响。基于这些发现和近期的出版物，骨化三醇在周围神经系统中可能发挥更大的作用。事实上，骨化三醇参与了髓鞘形成、周围神经的轴突同质性以及神经元细胞分化。这可能会带来有益的临床结果，因为补充骨化三醇可能是避免周围神经系统疾病发生和/或发展的一种简单方法。
