Cossio María L, Dubois Josée, McCuaig Catherine C, Coulombe Jérôme, Hatami Afshin, Marcoux Danielle, Ondrejchak Sandra, Powell Julie
Division of Dermatology, Department of Pediatrics, Sainte-Justine University Hospital Center, University of Montreal, Montreal, Quebec, Canada.
Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Pediatr Dermatol. 2019 Jul;36(4):466-470. doi: 10.1111/pde.13837. Epub 2019 Apr 29.
Non-involuting congenital hemangiomas (NICH) are fully formed vascular tumors at birth, with a distinctive clinical, radiologic, and histopathological profile, and classically lack expansion or involution over time. We describe a series of NICH cases with atypical postnatal growth.
The authors retrospectively analyzed all NICH cases diagnosed from 2007 to 2017. We reviewed charts and photographic databases from our Vascular Anomalies Clinic. We included in the study all NICH with an atypical postnatal growth. Clinical data, imaging, and histopathology were analyzed.
Eighty cases of NICH were identified. Nine presented with atypical postnatal growth after a stable period, at ages from 2 to 10 years (mean: 5.3 years). Two patients had associated pain; 5 patients showed new red papules on the surface of the lesion; 2 reported bleeding from the papules; and 1 developed a pyogenic granuloma. All patients had Doppler ultrasound and/or MRI compatible with NICH, and a confirmatory biopsy was performed in 4 cases. In treatment, 2 patients received endovascular embolization, and one required further surgery.
Non-involuting congenital hemangiomas (NICH) may develop significant postnatal growth over time (10% in our series), requiring closer follow-up for longer periods. The development of red papules, pyogenic granulomas, and superficial bleeding may be observed. Since this is a small series, we were not able to establish risk factors for NICH with postnatal growth.
非消退性先天性血管瘤（NICH）在出生时即为完全形成的血管肿瘤，具有独特的临床、放射学和组织病理学特征，且通常不会随时间扩展或消退。我们描述了一系列具有非典型出生后生长情况的NICH病例。
作者回顾性分析了2007年至2017年诊断的所有NICH病例。我们查阅了血管异常诊所的病历和照片数据库。本研究纳入了所有具有非典型出生后生长情况的NICH。对临床数据、影像学和组织病理学进行了分析。
共识别出80例NICH。9例在稳定期后出现非典型出生后生长，年龄为2至10岁（平均5.3岁）。2例患者伴有疼痛；5例患者病变表面出现新的红色丘疹；2例报告丘疹出血；1例发生化脓性肉芽肿。所有患者的多普勒超声和/或MRI结果均符合NICH，4例进行了确诊性活检。在治疗方面，2例患者接受了血管内栓塞，1例需要进一步手术。
非消退性先天性血管瘤（NICH）可能会随着时间推移出现显著的出生后生长（我们系列中的比例为10%），需要更长时间的密切随访。可能会观察到红色丘疹、化脓性肉芽肿和表面出血的发生。由于本系列病例较少（样本量小），我们未能确定出生后生长的NICH的危险因素。
