Matheis Tamara, Evinger Craig, Schubert Robin, Mazzola Steven, Fels Michaela, Kemper Nicole, Reilmann Ralf, Muratori Lisa
George-Huntington-Institute, Technology-Park, Muenster, Germany.
Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
J Huntingtons Dis. 2019;8(3):311-321. doi: 10.3233/JHD-180337.
The ability of healthy individuals to detect biological motion by using a small number of moving points is well established in animals and humans. Perception of human movements may depend on internal models that drive self-generated movements and influence motion discrimination (Reed CL et al. 1995 and 2007). As a person's motor repertoire deteriorates, the accuracy of these models may also decrease.
Determine if people with symptomatic Huntington's disease (HD) have difficulty perceiving movements.
In this study point-light displays were created with a Vicon Motion Capture System by recording one individual with (impaired) and one individual without (healthy) Parkinson's disease using a 13 joint marker set. Participants were asked to distinguish between three movements and determine if the movement was impaired or healthy. The ability of participants with and without HD to distinguish movement patterns and the time to perception were recorded.
Analyses found participants with HD had a decreased ability to correctly detect movements and point-light image type. The stair climbing motion showed the largest effect as participants with HD had more difficulty correctly identifying both the movement and whether it was impaired or healthy. In addition, the participants without HD showed an improvement as trials progressed which could not be observed in the HD cohort.
As people with symptomatic HD have difficulty perceiving movements further investigations using point-light displays should be done to determine if these impairments might serve as an easily administered, non-invasive marker of disease state.
健康个体利用少量移动点来检测生物运动的能力在动物和人类中已得到充分证实。对人类运动的感知可能依赖于驱动自我产生运动并影响运动辨别能力的内部模型（Reed CL等人，1995年和2007年）。随着一个人的运动技能逐渐退化，这些模型的准确性也可能降低。
确定有症状的亨廷顿舞蹈症（HD）患者在感知运动方面是否存在困难。
在本研究中，使用Vicon运动捕捉系统，通过用13个关节标记集记录一名帕金森病患者（有损伤）和一名非帕金森病患者（健康），创建了点光显示。要求参与者区分三种运动，并确定运动是否受损或健康。记录有HD和无HD的参与者区分运动模式的能力以及感知时间。
分析发现，有HD的参与者正确检测运动和点光图像类型的能力下降。爬楼梯运动的影响最大，因为有HD的参与者在正确识别运动以及运动是否受损或健康方面更困难。此外，无HD的参与者随着试验的进行表现出改善，而在HD队列中未观察到这种情况。
由于有症状的HD患者在感知运动方面存在困难，应使用点光显示进行进一步研究，以确定这些损伤是否可作为疾病状态的一种易于实施的非侵入性标志物。
