Kashimoto S, Tsuji Y, Kumazawa T
Acta Anaesthesiol Scand. 1987 Jan;31(1):44-7. doi: 10.1111/j.1399-6576.1987.tb02518.x.
In experiments on isolated rat heart-lung preparation, the effects of halothane and enflurane on myocardial metabolism during postischaemic reperfusion were evaluated with intramyocardial high energy phosphates, lactate and glycogen. Hearts were perfused for 10 min initially and made globally ischaemic for 8 min. Afterwards, they were reperfused for 12 min. Halothane or enflurane was administered from 5 min after the start of perfusion to the end of reperfusion. There were no significant differences in contents of high energy phosphates between control (C), halothane (H) and enflurane (E) groups (ATP: 15.50 +/- 0.87, 16.05 +/- 1.99 and 15.16 +/- 2.03 mumol/g dry wt, respectively). However, lactate levels in the hearts in Groups H and E were significantly higher than those in Group C (44.04 +/- 10.54, 40.63 +/- 10.34 vs 28.63 +/- 5.98). Slight deterioration in the myocardial oxidation-reduction state may be caused by inhalational anaesthetics when they are administered during the postischaemic reperfusion period.
在对离体大鼠心肺标本进行的实验中，使用心肌高能磷酸盐、乳酸和糖原评估了氟烷和恩氟烷在缺血后再灌注期间对心肌代谢的影响。心脏最初灌注10分钟，然后整体缺血8分钟。之后，再灌注12分钟。从灌注开始后5分钟至再灌注结束期间给予氟烷或恩氟烷。对照组（C）、氟烷组（H）和恩氟烷组（E）之间的高能磷酸盐含量无显著差异（ATP：分别为15.50±0.87、16.05±1.99和15.16±2.03μmol/g干重）。然而，H组和E组心脏中的乳酸水平显著高于C组（44.04±10.54、40.63±10.34对28.63±5.98）。吸入麻醉药在缺血后再灌注期间给药时，可能会导致心肌氧化还原状态略有恶化。
