Padarathsingh M L, Dean J H, McCoy J L, Lewis D D, Northing J W
Cancer Treat Rep. 1978 Nov;62(11):1627-35.
Restorative effects of levamisole on general and tumor-associated cell-mediated immune responses were investigated following aniline mustard (AM) chemotherapy of BALB/c mice bearing ADJ-PC5 plasmacytoma. Total eradication of tumor following AM chemotherapy resulted in severe depression of lymphoproliferative (LP) responses which recovered after a prolonged period of 4-6 weeks. During this time, spleen cells from these treated mice were shown to be generally depressed to T- and B-cell mitogens. Levamisole, an anthelmintic drug capable of enhancing depressed immune responses in mice and in man, was employed following AM chemotherapy in an attempt to restore immunocompetency. Administration of levamisole following AM had a significant effect on the ability of mice to resist rechallenge with ADJ-PC5 tumor and in tumor cell neutralization. The enhanced resistance to tumor cell challenge appeared to be associated with a faster recovery of the general T-cell immunocompetence as demonstrated in the LP assays among the mice receiving chemotherapy followed by adjuvant therapy. Levamisole, when administered alone to tumor-bearing mice, did not appear to possess a direct antitumor effect. In addition, levamisole did not potentiate cellular immunity to higher than normal levels in nonimmunodepressed mice. These results demonstrate the efficacy of levamisole as a restorative agent of the general and tumor-associated immunocompetency in the immunodepressed host.
在对携带ADJ - PC5浆细胞瘤的BALB/c小鼠进行苯胺芥子气（AM）化疗后，研究了左旋咪唑对全身及肿瘤相关细胞介导免疫反应的恢复作用。AM化疗后肿瘤的完全清除导致淋巴细胞增殖（LP）反应严重受抑，这种情况在4 - 6周的较长时间后才恢复。在此期间，这些接受治疗的小鼠的脾细胞对T细胞和B细胞有丝分裂原的反应普遍受到抑制。左旋咪唑是一种能够增强小鼠和人类受抑免疫反应的驱虫药，在AM化疗后使用，试图恢复免疫能力。AM化疗后给予左旋咪唑对小鼠抵抗ADJ - PC5肿瘤再次攻击的能力以及肿瘤细胞中和能力有显著影响。对肿瘤细胞攻击的抵抗力增强似乎与全身T细胞免疫能力更快恢复有关，这在接受化疗后再进行辅助治疗的小鼠的LP试验中得到了证明。单独给荷瘤小鼠施用左旋咪唑时，似乎不具有直接抗肿瘤作用。此外，左旋咪唑在未免疫抑制的小鼠中不会将细胞免疫增强到高于正常水平。这些结果证明了左旋咪唑作为免疫抑制宿主中全身及肿瘤相关免疫能力恢复剂的功效。
