von Huth Sebastian, Kofoed Poul-Erik, Holmskov Uffe
Cancer and Inflammation Research, Department of Molecular Medicine, University of Southern Denmark, J. B. Winslows, Odense C, Denmark.
Department of Pediatrics, Kolding Hospital, Skovvangen 2-8, Kolding, Denmark.
Trans R Soc Trop Med Hyg. 2019 Sep 6;113(9):545-554. doi: 10.1093/trstmh/trz032.
Gastrointestinal (GI) parasitic infections cause significant morbidity and mortality in tropical and subtropical countries. We aimed to investigate the prevalence of GI parasitic infections in children from Bissau, Guinea-Bissau and to identify the possible risk factors for these infections.
We performed an observational study on two comparable cohorts of children 2-15 y of age: one study covering health care-seeking children (n=748) and one study covering children from the background population (n=851). A total of 1274 faecal samples from the two cohorts were investigated for parasites by microscopy and the risk factors for infection were identified by logistic regression.
Intestinal parasitic infections were found in 54.8% of health care-seeking children and 55.5% of children from the background population. Helminth infections were more common among health care-seeking children and were mainly due to hookworms. Pathogenic protozoa included Entamoeba histolytica/dispar and Giardia lamblia. The risk factors for infections included increasing age, household crowding and poor sanitation and water supply.
We found a high prevalence of intestinal parasites among both health care-seeking children and children from the background population. Compared with previous studies, we found a decreasing prevalence of intestinal helminths. This study further identifies potential risk factors for infections, including inadequate sanitation and water supply.
胃肠道寄生虫感染在热带和亚热带国家导致了显著的发病率和死亡率。我们旨在调查几内亚比绍比绍市儿童胃肠道寄生虫感染的患病率，并确定这些感染的可能危险因素。
我们对两个年龄在2至15岁的可比儿童队列进行了一项观察性研究：一项研究涵盖寻求医疗服务的儿童（n = 748），另一项研究涵盖来自背景人群的儿童（n = 851）。通过显微镜检查对两个队列的总共1274份粪便样本进行寄生虫检测，并通过逻辑回归确定感染的危险因素。
在寻求医疗服务的儿童中，54.8%被发现有肠道寄生虫感染，在来自背景人群的儿童中这一比例为55.5%。蠕虫感染在寻求医疗服务的儿童中更为常见，主要是由钩虫引起的。致病性原生动物包括溶组织内阿米巴/迪氏内阿米巴和蓝氏贾第鞭毛虫。感染的危险因素包括年龄增长、家庭拥挤以及卫生和供水条件差。
我们发现寻求医疗服务的儿童和来自背景人群的儿童中肠道寄生虫感染的患病率都很高。与以前的研究相比，我们发现肠道蠕虫的患病率在下降。这项研究进一步确定了感染的潜在危险因素，包括卫生和供水不足。
