Langston J W
Am Fam Physician. 1987 Mar;35(3):201-6.
MPTP, a reverse ester of meperidine, is one of a number of "designer drugs" that have recently flooded the California drug market. Young adults who have used this drug have developed classic Parkinson's disease. The discovery that MPTP is selectively toxic to the substantia nigra has revitalized basic research on Parkinson's disease. New therapeutic strategies have been suggested, and new techniques may make it possible to detect the disease in its preclinical stage.
MPTP是哌替啶的一种反向酯，是近期充斥加利福尼亚毒品市场的众多“设计毒品”之一。使用过这种毒品的年轻人患上了典型的帕金森病。MPTP对黑质具有选择性毒性这一发现，重振了帕金森病的基础研究。人们提出了新的治疗策略，新技术或许能在临床前阶段检测出该疾病。
