Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.
Division of Endocrinology, Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
FASEB J. 2019 Aug;33(8):8925-8934. doi: 10.1096/fj.201802754R. Epub 2019 Apr 29.
Mitochondrial metabolic plasticity is a key adaptive mechanism in response to changes in cellular metabolic demand. Changes in mitochondrial metabolic efficiency have been linked to pathophysiological conditions, including cancer, neurodegeneration, and obesity. The ubiquitously expressed (Parkinsonism-associated deglycase) is known as a Parkinson's disease gene and an oncogene. The pleiotropic functions of include reactive oxygen species scavenging, RNA binding, chaperone activity, endocytosis, and modulation of major signaling pathways involved in cell survival and metabolism. Nevertheless, how these functions are linked to the role of in mitochondrial plasticity is not fully understood. In this study, we describe an interaction between and that regulates the localization of , in a hypoxia-dependent manner, either to the cytosol or to mitochondria. This interaction acts as a modulator of mitochondrial metabolic efficiency and a switch between glycolysis and oxidative phosphorylation. Modulation of this novel molecular mechanism of mitochondrial metabolic efficiency is potentially involved in the neuroprotective function of as well as its role in proliferation of cancer cells.-Weinert, M., Millet, A., Jonas, E. A., Alavian, K. N. The mitochondrial metabolic function of is modulated by .
线粒体代谢可塑性是细胞代谢需求变化时的一种关键适应机制。线粒体代谢效率的变化与生理病理状况有关，包括癌症、神经退行性疾病和肥胖。广泛表达的（Parkinsonism-associated deglycase）被称为帕金森病基因和癌基因。的多效性功能包括清除活性氧、RNA 结合、伴侣活性、内吞作用以及调节涉及细胞存活和代谢的主要信号通路。然而，这些功能如何与在线粒体可塑性中的作用相关尚不完全清楚。在这项研究中，我们描述了一种相互作用，即和在缺氧依赖的情况下相互作用，调节的定位，要么到细胞质，要么到线粒体。这种相互作用作为线粒体代谢效率的调节剂和糖酵解与氧化磷酸化之间的转换开关。这种新的线粒体代谢效率的分子机制的调节可能与的神经保护功能及其在癌细胞增殖中的作用有关。-Weinert，M.，Millet，A.，Jonas，E. A.，Alavian，K. N. 由 调节线粒体代谢功能。
