Gault Gilbert, Lefebvre Sébastien, Benoit Etienne, Lattard Virginie, Grancher Denis
USC 1233 RS2GP, INRA-VetAgro Sup, 1 Avenue Bourgelat, Marcy l'Etoile, 69280, France.
USC 1233 RS2GP, INRA-VetAgro Sup, 1 Avenue Bourgelat, Marcy l'Etoile, 69280, France.
Toxicon. 2019 Jul;165:47-55. doi: 10.1016/j.toxicon.2019.04.010. Epub 2019 Apr 26.
Few studies have reported quantitative data about the levels of prenylated coumarins in Ferula sp. Yet, the toxicity of Ferula sp. is only due to the presence of prenylated coumarins and to their concentrations and all studies suggest the existence of several chemotypes within the same species or even within the same variety. The aim of this study was to investigate the hypothesis of different chemotypes in french Ferula sp. in relationship with the botanical species. In this objective, the species of giant fennels and their concentrations in prenylated coumarins were explored. Three different species or subspecies of giant fennel were detected in continental France: F. communis communis communis L., F. communis catalaunica microcarpa Cauwet-Marc and F. glauca L. Surprisingly, the three species/subspecies of giant fennels were found to be located in exclusive and well separated geographical areas. In French giant fennels, ferulenol and ferprenin were detected. Distribution of ferulenol and ferprenin were found to be different between botanical varieties, but also according to the season, the soil and the altitude. Our study seems to suggest that among F. communis species, the same plant can be regarded as poisonous at one point and another as non-poisonous.
很少有研究报告过阿魏属植物中异戊烯基香豆素含量的定量数据。然而，阿魏属植物的毒性仅归因于异戊烯基香豆素的存在及其浓度，并且所有研究都表明同一物种甚至同一变种内存在几种化学型。本研究的目的是调查法国阿魏属植物中不同化学型与植物物种之间关系的假设。为此，对巨型茴香的物种及其异戊烯基香豆素的浓度进行了探索。在法国大陆检测到三种不同的巨型茴香物种或亚种：普通阿魏、卡塔洛尼卡阿魏和灰绿阿魏。令人惊讶的是，这三种巨型茴香物种/亚种位于相互独立且分隔良好的地理区域。在法国巨型茴香中，检测到了阿魏醇和阿魏菌素。发现阿魏醇和阿魏菌素的分布在植物变种之间不同，而且还因季节、土壤和海拔而异。我们的研究似乎表明，在普通阿魏物种中，同一株植物在某一时刻可能被视为有毒，而在另一时刻则被视为无毒。
