Department of Medical Technology, Kawasaki University of Medical Welfare, Okayama, 701-0193, Japan.
Division of Food and Nutrition, Nakamura Gakuen University Junior College, Fukuoka, 814-0198, Japan.
Biomed Pharmacother. 2019 Jul;115:108879. doi: 10.1016/j.biopha.2019.108879. Epub 2019 Apr 28.
Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20 min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects.
香草醛广泛应用于食品和化妆品等物质中，因其具有甜味。然而，香草醛吸入的神经心理学影响尚未阐明。在这项研究中，我们调查了香草醛吸入对小鼠行为的影响。首先，我们研究了香草醛的香气对小鼠是有吸引力还是有排斥力。此后，在一系列行为测试（高架十字迷宫、旷场、Y 迷宫、悬尾、棉签咬和 Porsolt 强迫游泳测试）之前，每组小鼠均吸入香草醛 20 分钟。在这些测试中，小鼠对香草醛表现出中性反应。吸入香草醛的小鼠在热板测试中对疼痛的反应受到抑制。此外，吸入香草醛的小鼠的前肢握力下降。吸入香草醛的小鼠与对照组小鼠在旷场、Y 迷宫、悬尾、强迫游泳和攻击测试中没有发现显著差异。这些结果表明，香草醛吸入具有与其他给药途径相似的抗伤害感受作用。结果还表明，香草醛吸入不会引起明显的行为影响。
