Semon C, Dupond J L, Mallet H, Grandmottet-Cambefort C, Humbert P
Ann Endocrinol (Paris). 1986;47(5):399-402.
A 31 year old woman suffering of acute intermittent porphyria (AIP) developed within 9 months 7 cyclical attacks occurring in a average of 5,2 days before menses. In order to inhibit ovulation, we experiment a long-acting agonist LH-RH (D-SER (TBU) 6-EA10 LH-RH--Buserelin) administered during 8 months by nasal spray. Menses did not occur during the test and the patient developed only 2 attacks. The initial ovarian stimulation phase lasted 15 days and was marked by the induction of an AIP attack after 3 days of treatment and occurrence of ovarian cysts. Our case suggests that LH-RH analogues may be useful in the prevention of cyclical attacks of porphyria.
一名31岁患有急性间歇性卟啉病(AIP)的女性在9个月内出现了7次周期性发作,平均在月经前5.2天发作。为了抑制排卵,我们通过鼻喷雾剂对一种长效促黄体生成素释放激素激动剂(D-丝氨酸(叔丁基)6-乙酰胺基-10-促黄体生成素释放激素——布舍瑞林)进行了为期8个月的试验。试验期间月经未出现,患者仅发作了2次。初始卵巢刺激阶段持续了15天,其特征是治疗3天后诱发了一次AIP发作以及出现了卵巢囊肿。我们的病例表明,促黄体生成素释放激素类似物可能有助于预防卟啉病的周期性发作。