基于单宁酸核的可降解聚合物星型结构的原子转移自由基聚合制备法

Degradable Polymer Stars Based on Tannic Acid Cores by ATRP.

作者信息

Cuthbert Julia, Yerneni Saigopalakrishna S, Sun Mingkang, Fu Travis, Matyjaszewski Krzysztof

机构信息

Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.

出版信息

Polymers (Basel). 2019 Apr 28;11(5):752. doi: 10.3390/polym11050752.

DOI:10.3390/polym11050752

PMID:31035360

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6571670/

Abstract

Degradable polymers are crucial in order to reduce plastic environmental pollution and waste accumulation. In this paper, a natural product, tannic acid was modified to be used as a polymer star core. The tannic acid was modified with atom transfer radical polymerization (ATRP) initiators and characterized by H NMR, FT-IR, and XPS. Twenty-five arm polymer stars were prepared by photoinduced ATRP of poly(methyl methacrylate) (PMMA) or poly(oligo(ethylene oxide) methacrylate) (molar mass M = 300 g/mol) (P(OEOMA)). The polymer stars were degraded by cleaving the polymer star arms attached to the core by phenolic esters under mild basic conditions. The stars were analyzed before and after degradation by gel permeation chromatography (GPC). Cytotoxicity assays were performed on the P(OEOMA) stars and corresponding degraded polymers, and were found to be nontoxic at the concentrations tested.

摘要

为了减少塑料对环境的污染和废弃物的积累，可降解聚合物至关重要。在本文中，一种天然产物单宁酸被改性用作聚合物星形核。单宁酸用原子转移自由基聚合（ATRP）引发剂进行改性，并通过核磁共振氢谱（H NMR）、傅里叶变换红外光谱（FT-IR）和X射线光电子能谱（XPS）进行表征。通过聚甲基丙烯酸甲酯（PMMA）或聚（甲基丙烯酸寡聚环氧乙烷酯）（摩尔质量M = 300 g/mol）（P（OEOMA））的光引发ATRP制备了二十五臂聚合物星。在温和的碱性条件下，通过酚酯切断连接在核上的聚合物星臂，聚合物星发生降解。在降解前后通过凝胶渗透色谱（GPC）对星形聚合物进行分析。对P（OEOMA）星形聚合物和相应的降解聚合物进行了细胞毒性试验，发现在测试浓度下它们无毒。