Amoretti Silvia, Cabrera Bibiana, Torrent Carla, Bonnín Caterina Del Mar, Mezquida Gisela, Garriga Marina, Jiménez Esther, Martínez-Arán Anabel, Solé Brisa, Reinares Maria, Varo Cristina, Penadés Rafael, Grande Iria, Salagre Estela, Parellada Eduard, Bioque Miquel, Garcia-Rizo Clemente, Meseguer Ana, Anmella Gerard, Rosa Adriane R, Contreras Fernando, Safont Gemma, Vieta Eduard, Bernardo Miquel
Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, 08036 Barcelona, Spain.
Biomedical Research Networking Center for Mental Health (CIBERSAM), 28029 Madrid, Spain.
J Clin Med. 2019 Apr 28;8(5):586. doi: 10.3390/jcm8050586.
(1) Background: The cognitive reserve (CR) concept has not been precisely defined in severe mental disorders and has been estimated using heterogeneous methods. This study aims to investigate and develop the psychometric properties of the Cognitive Reserve Assessment Scale in Health (CRASH), an instrument designed to measure CR in people with severe mental illness; (2) Methods: 100 patients with severe mental illness (non-affective psychoses and affective disorders) and 66 healthy controls were included. The internal consistency and convergent validity of CRASH were assessed. Spearman's correlations coefficients were also performed to examine the relationship between CRASH and neuropsychological tests, psychosocial functioning, and clinical course; (3) Results: The internal consistency was high (Cronbach's alpha coefficient = 0.903). The CRASH global score had a large positive correlation with the Cognitive reserve questionnaire total score ( = 0.838, < 0.001), demonstrating good convergent validity. The correlation coefficients between the CRASH total scores and clinical, functional, and neuropsychological performance were different between groups. In order to provide clinical interpretation, severity classification based on diagnosis (non-affective psychotic disorders, affective disorders, and healthy controls) have been created; (4) Conclusions: CRASH is the first CR measure developed specifically for patients with severe mental illness, facilitating reliable and valid measurement of this construct. The scale may aid in the stratification of patients and the implementation of personalized interventions.
(1) 背景：认知储备（CR）概念在严重精神障碍中尚未得到精确界定，且一直通过异质性方法进行评估。本研究旨在调查并开发健康认知储备评估量表（CRASH）的心理测量特性，该量表旨在测量严重精神疾病患者的认知储备；(2) 方法：纳入100例严重精神疾病患者（非情感性精神病和情感障碍）及66名健康对照。评估CRASH的内部一致性和收敛效度。还进行了斯皮尔曼相关系数分析，以检验CRASH与神经心理学测试、社会心理功能及临床病程之间的关系；(3) 结果：内部一致性较高（克朗巴赫α系数 = 0.903）。CRASH总体得分与认知储备问卷总分呈高度正相关（ = 0.838， < 0.001），显示出良好的收敛效度。两组之间CRASH总分与临床、功能及神经心理学表现的相关系数有所不同。为提供临床解释，已根据诊断（非情感性精神障碍、情感障碍及健康对照）创建了严重程度分类；(4) 结论：CRASH是首个专门为严重精神疾病患者开发的认知储备测量工具，有助于对该结构进行可靠且有效的测量。该量表可能有助于患者分层及个性化干预的实施。
