Chen Hao, Wang Xiaohua, Yao Shan, Raza Hafiz Khuram, Jing Jia, Cui Guiyun, Hua Fang
a Department of Neurology , The Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
b Xuzhou Central Hospital , Xuzhou , China.
Somatosens Mot Res. 2019 Jun;36(2):102-108. doi: 10.1080/08990220.2019.1609438. Epub 2019 Apr 30.
To strengthen the understanding, increase the early diagnostic rate, and improve the outcome of unilateral oculomotor nerve palsy through the analysis of the 121 patients suffering from this disease in our hospital. A retrospective study was performed on the 121 patients with unilateral oculomotor nerve palsy diagnosed at the Affiliated Hospital of Xuzhou Medical University from October 2014 to October 2015. The clinical data, such as gender, age, aetiology, clinical features, laboratory tests, and six months follow up reports were analyzed. The main causes identified in the 121 patients with unilateral oculomotor nerve palsy were intracranial aneurysm (29.8%), diabetic peripheral neuropathy (26.5%), painful ophthalmoplegia (9.9%), and other causes (33.9%). The results from the six month follow up showed that in all the patients, 53.7% were fully recovered, 38.0% improved, and 8.3% had no significant change in symptoms. The results also indicated that the patients with diabetic peripheral neuropathy had the best outcome with 71.9% full recovery rate, which was significantly higher than that in the patients with intracranial aneurysm (36.1%, < .05), and idiopathic causes (44.5%, < .05). Our data indicates that intracranial aneurysm is the leading cause of unilateral oculomotor nerve palsy, and that diabetic peripheral neuropathy has better outcome. Understanding the common causes and clinical features of unilateral oculomotor nerve paralysis is helpful for its early diagnosis and treatment.
通过对我院121例单侧动眼神经麻痹患者的分析，加强认识，提高早期诊断率，改善其治疗效果。对2014年10月至2015年10月在徐州医科大学附属医院确诊的121例单侧动眼神经麻痹患者进行回顾性研究。分析了患者的性别、年龄、病因、临床特征、实验室检查及6个月随访报告等临床资料。121例单侧动眼神经麻痹患者的主要病因包括颅内动脉瘤（29.8%）、糖尿病周围神经病变（26.5%）、痛性眼肌麻痹（9.9%）和其他病因（33.9%）。6个月随访结果显示，所有患者中，53.7%完全恢复，38.0%有所改善，8.3%症状无明显变化。结果还表明，糖尿病周围神经病变患者的治疗效果最佳，完全恢复率为71.9%，显著高于颅内动脉瘤患者（36.1%，P<0.05）和特发性病因患者（44.5%，P<0.05）。我们的数据表明，颅内动脉瘤是单侧动眼神经麻痹的主要病因，糖尿病周围神经病变的治疗效果较好。了解单侧动眼神经麻痹的常见病因和临床特征有助于其早期诊断和治疗。
