Marino D, Marino M T, Bolis L, Milhaud G
Biomed Pharmacother. 1986;40(9):345-8.
The effect of the calcium-ionophore A23187+ Ca++ on the K+ transport in the intact erythrocytes of sea-water fishes was investigated. A23187+ Ca++ induced a significant increase in the cell-membrane permeability for potassium ion, while A23187+ Mg++ was ineffective. Addition of EGTA to the medium blocked the ionophore+ Ca++ effect. Quinidine inhibited the A23187+ Ca++-induced K+ transport in the nucleated fish red cell. Propranolol is effective in the fish RBC in presence of Ca++ and EGTA. The relationship of the calcium-induced alkali cation transport in nucleated red cell to that in human red cell is discussed.
研究了钙离子载体A23187 + Ca++对海水鱼类完整红细胞中钾离子转运的影响。A23187 + Ca++可显著增加细胞膜对钾离子的通透性，而A23187 + Mg++则无效。向培养基中添加乙二醇双四乙酸（EGTA）可阻断离子载体+ Ca++的作用。奎尼丁抑制有核鱼红细胞中A23187 + Ca++诱导的钾离子转运。在存在Ca++和EGTA的情况下，普萘洛尔对鱼类红细胞有效。文中讨论了有核红细胞中钙诱导的碱金属阳离子转运与人类红细胞中该转运的关系。
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