Improved Pharma, Purdue University, West Lafayette, Indiana, USA.
Purdue University, 355 Union Place Summit, New Jersey, NJ, USA.
AAPS PharmSciTech. 2019 Apr 29;20(5):176. doi: 10.1208/s12249-019-1375-2.
Predictive formulation design and accelerated formulation design can lead to the discovery of useful formulations to support drug clinical studies and successful drug approval. Predictive formulation design can also lead to discovery of a path for commercialization, especially for poorly soluble drugs, when the target product profile is well defined and a "learning before doing" approach is implemented. One of the key components of predictive/accelerated formulation design is to understand and leverage the material properties of drug substance including solubility, BCS classification, polymorphs, salt formation, amorphous form, amorphous complex, and stability. In addition, utilizing synchrotron-based PDF (pair distribution function) analysis can provide important structural information for the formulation. This knowledge allows control of physical and chemical stability of the designed product. Finally, formulation design should link to process development following Quality by Design principles, and solid-state chemistry should play a critical role in many of the steps required to achieve Quality by Design, which can lead to successful product development.
预测性制剂设计和加速制剂设计可以发现有用的制剂，以支持药物临床研究和成功的药物批准。当目标产品特性得到很好的定义并实施“先学习后行动”的方法时，预测性制剂设计也可以为商业化探索一条道路，特别是对于溶解度差的药物。预测性/加速制剂设计的一个关键组成部分是了解和利用药物物质的材料特性，包括溶解度、BCS 分类、多晶型、盐形成、无定形形式、无定形复合物和稳定性。此外，利用基于同步加速器的 PDF（配分函数）分析可以为制剂提供重要的结构信息。这些知识可以控制设计产品的物理和化学稳定性。最后，制剂设计应遵循质量源于设计原则与工艺开发相联系，固态化学应该在实现质量源于设计所需的许多步骤中发挥关键作用，这可以导致成功的产品开发。
