Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry , Chinese Academy of Sciences , Beijing 100190 , People's Republic of China.
School of Future Technology , University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
ACS Appl Mater Interfaces. 2019 May 22;11(20):18178-18185. doi: 10.1021/acsami.9b03270. Epub 2019 May 9.
Natural products show high potential for clinical translation because of their specific biological activities and molecular structure diversities. Sonosensitizers that originate from natural products play a crucial role as anti-inflammatory and anticancer agents. Herein, hypocrellin-derivative nanoparticles (APHB NPs) were constructed for synchronous near-infrared fluorescence (NIR FL) imaging and sonodynamic therapy (SDT) for deep-seated tumors in vivo. The prepared APHB NPs exhibit excellent water solubility, FL in the NIR region, and effective reactive oxygen species generation under ultrasound stimulation. Furthermore, the APHB NPs show excellent biocompatibility, suitable biodegradation rate, and enhanced tumor accumulation. Therefore, the APHB NPs exhibit promising clinical potential as novel safe and precise NIR FL imaging and SDT agents for deep-seated tumor therapy.
天然产物因其特定的生物活性和分子结构多样性而显示出很高的临床转化潜力。源于天然产物的声敏剂作为抗炎和抗癌药物发挥着关键作用。在此，构建了竹红菌素衍生物纳米颗粒（APHB NPs），用于体内深部肿瘤的同步近红外荧光（NIR FL）成像和声动力治疗（SDT）。所制备的 APHB NPs 表现出优异的水溶性、NIR 区域的 FL 以及超声刺激下有效产生活性氧的能力。此外，APHB NPs 表现出优异的生物相容性、合适的降解率和增强的肿瘤积累。因此，APHB NPs 有望成为新型安全、精确的深部肿瘤治疗的 NIR FL 成像和 SDT 试剂，具有广阔的临床应用前景。
