Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
J Matern Fetal Neonatal Med. 2021 Feb;34(4):555-561. doi: 10.1080/14767058.2019.1610738. Epub 2019 Apr 30.
To evaluate the elements more likely to be associated with premature rupture of membrane (PROM) in patients that use assisted reproductive technology (ART). A retrospective case-control study was performed from January 2014 to August 2017. We included 301 patients, 257 patients were without PROM in the non-PROM group and 44 patients with PROM in the PROM group. In the PROM group, the rate of intracytoplasmic sperm injection (ICSI) and BMI were significantly higher than the non-PROM group. Moreover, the rate of preterm birth was significantly higher in the PROM group. When using logistic regression analysis to decrease the impact of confounding factors, it showed that overweight and ICSI were confirmed to be associated with PROM. After matching 1:2 by BMI, the process of controlled ovarian hyperstimulation was all similar in the two groups. What is more, the rate of twin pregnancies was significantly higher in the preterm PROM (PPROM) group compared with the term PROM group and twin pregnancies were associated with preterm birth. ART parameters ICSI may increase the risk of PROM. Single embryo transfer during ART should be supported to decrease the incidence of PPROM and losing weight is essential for patients before embarking on ART.
评估辅助生殖技术（ART）患者中更可能与胎膜早破（PROM）相关的因素。
这是一项 2014 年 1 月至 2017 年 8 月进行的回顾性病例对照研究。共纳入 301 例患者，其中 257 例患者无 PROM（非 PROM 组），44 例患者有 PROM（PROM 组）。在 PROM 组中，卵胞浆内单精子注射（ICSI）和 BMI 的比例明显高于非 PROM 组，且 PROM 组的早产率明显更高。当使用逻辑回归分析降低混杂因素的影响时，结果显示超重和 ICSI 与 PROM 相关。在按 BMI 进行 1:2 匹配后，两组的控制性卵巢刺激过程相似。更重要的是，与足月 PROM 组相比，早产 PROM（PPROM）组的双胞胎妊娠率明显更高，且双胞胎妊娠与早产相关。ART 参数 ICSI 可能会增加 PROM 的风险。ART 期间应支持单胚胎移植，以降低 PPROM 的发生率，并且对于接受 ART 的患者来说，减肥是至关重要的。
