使用左炔诺孕酮皮下埋植剂期间的甲状腺功能情况

Aspects of thyroid function during use of Norplant implants.

作者信息

Olsson S E, Wide L, Odlind V

出版信息

Contraception. 1986 Dec;34(6):583-7. doi: 10.1016/s0010-7824(86)80014-2.

Abstract

Plasma thyroxin (T4), triiodothyronine (T3), T3-uptake and thyroid stimulating hormone (TSH) were measured in 18 women using Norplant implants or Norplant-2 implants for six months. Free T4-index and free T3-index were also calculated. All women had used non-hormonal contraceptives before insertion of the implants. T4 decreased and T3-uptake increased, indicating a lower level of thyroid binding proteins during treatment. Free T4-index remained unchanged, indicating that the free concentration of thyroxin was unaltered. All women were euthyroid and TSH was unchanged. It is concluded that treatment with Norplant implants does not result in a change in thyroid function.

摘要

对18名使用左炔诺孕酮皮下埋植剂或第二代左炔诺孕酮皮下埋植剂6个月的女性进行了血浆甲状腺素（T4）、三碘甲状腺原氨酸（T3）、T3摄取率及促甲状腺激素（TSH）的测定。还计算了游离T4指数和游离T3指数。所有女性在植入埋植剂前均使用过非激素避孕药。T4降低，T3摄取率升高，表明治疗期间甲状腺结合蛋白水平降低。游离T4指数保持不变，表明甲状腺素的游离浓度未改变。所有女性甲状腺功能正常，TSH无变化。结论是，使用左炔诺孕酮皮下埋植剂治疗不会导致甲状腺功能改变。