H-2 相同的骨髓细胞在免疫小鼠脾细胞体内抗肿瘤活性中的协作。
The collaboration of H-2 identical bone marrow cells in in vivo antitumor activity of immune mouse splenocytes.
作者信息
Ozawa H, Iwaguchi T, Kataoka T
出版信息
Jpn J Cancer Res. 1987 Feb;78(2):113-6.
PMID:3104253
Abstract
Antitumor activity of Meth A-immune BALB/c mouse spleen cells (Meth A-Im-SPL) was assayed by a Winn test in CD-1(nu/nu) or BALB/c(nu/nu) chimeric mice which were reconstituted with the bone marrow cells of various strains of mice. It was found that Meth A-Im-SPL (L3T4+ T cells) neutralized the tumor in collaboration with H-2 compatible bone marrow or bone marrow-derived cells.
摘要
通过Winn试验在由各种品系小鼠的骨髓细胞重建的CD-1（裸/裸）或BALB/c（裸/裸）嵌合小鼠中检测Meth A免疫的BALB/c小鼠脾细胞（Meth A-Im-SPL）的抗肿瘤活性。发现Meth A-Im-SPL（L3T4 + T细胞）与H-2相容的骨髓或骨髓衍生细胞协同作用中和肿瘤。
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