Department of Otorhinolaryngology, the First Affiliated Hospital of Medical College in Zhejiang University, 79(#) Qingchun Street, Hangzhou, Zhejiang, China.
Department of Otorhinolaryngology, the First Affiliated Hospital of Medical College in Zhejiang University, 79(#) Qingchun Street, Hangzhou, Zhejiang, China.
Neurosci Lett. 2019 Jul 13;705:235-245. doi: 10.1016/j.neulet.2019.04.046. Epub 2019 Apr 28.
The study investigated the alteration of brain functional connectivity (FC) patterns and analyzed the relationship between FC and psychological statue in pulsatile tinnitus (PT) patients by resting-state functional magnetic resonance imaging. The eligible PT patients (29) and healthy subjects (29) were enrolled. Brain activity, FC and clinical characteristics, including tinnitus handicap inventory, duration, sleep quality, anxiety, and depression were evaluated. A significantly increased brain activity in the left cerebellum and left inferior temporal gyrus was observed in PT patients. An abnormally increased FC was focused on the left cerebellum and left inferior temporal gyrus, right superior temporal gyrus, and right occipital gyrus, as well as, the inferior temporal gyrus and thalamus, the putamen and caudate nucleus. Decreased FC was demonstrated between the left cerebellum and bilateral angular gyrus, as well as, the left inferior temporal gyrus and orbital gyrus of the medial prefrontal lobe. A negative correlation was established between the scores of sleep quality and anxiety and the values of FC (in the inferior temporal gyrus and bilateral thalamus). These results suggest an abnormal activity of non-auditory cortex (the cerebellum and inferior temporal gyrus), and the alteration of FC patterns are responsible for PT. Some psychological factors may not be correlated with FC in PT patients.
本研究通过静息态功能磁共振成像（rs-fMRI）来探讨搏动性耳鸣（PT）患者脑功能连接（FC）模式的改变，并分析 FC 与心理状态之间的关系。纳入了 29 名符合条件的 PT 患者和 29 名健康对照者。评估了脑活动、FC 以及包括耳鸣残疾量表、持续时间、睡眠质量、焦虑和抑郁在内的临床特征。PT 患者的左侧小脑和左侧颞下回的脑活动明显增加。异常增加的 FC 主要集中在左侧小脑和左侧颞下回、右侧颞上回和右侧枕叶，以及颞下回和丘脑、壳核和尾状核。左侧小脑与双侧角回之间以及左侧颞下回与眶额回之间的 FC 减少。睡眠质量和焦虑评分与 FC 值（在颞下回和双侧丘脑）之间呈负相关。这些结果表明非听觉皮层（小脑和颞下回）的活动异常以及 FC 模式的改变可能是导致 PT 的原因。一些心理因素可能与 PT 患者的 FC 无关。
