Kuokkanen K, Niemi K M, Reunala T
J Cutan Pathol. 1987 Feb;14(1):54-8. doi: 10.1111/j.1600-0560.1987.tb00127.x.
We describe a patient who in association with myeloma developed generalized keratotic horns. Light microscopy revealed parakeratotic plugs resembling those seen in Kyrle's disease. Electron microscopy showed distortion of keratinosomes and laminated bodies indicating a profound disturbance in keratinization. A strong C3 and weaker IgG and IgA immunofluorescence were seen in the areas of epidermal plugs and horns but no circulating epidermal antibodies were detected. All symptoms disappeared when therapy for myeloma was started favoring that they were of paraneoplastic origin.
我们描述了一名与骨髓瘤相关的患者，其出现了全身性角化性角。光学显微镜检查显示角化不全性栓子，类似于见于 Kyrle 病的栓子。电子显微镜检查显示角质小体和板层小体变形，表明角质化存在严重紊乱。在表皮栓子和角的区域可见强 C3 以及较弱的 IgG 和 IgA 免疫荧光，但未检测到循环表皮抗体。开始进行骨髓瘤治疗后所有症状消失，这表明它们是副肿瘤性起源。
