Myllynen P, Kammonen M, Rokkanen P, Böstman O, Lalla M, Laasonen E, Vahtera E
J Trauma. 1987 Mar;27(3):287-90.
Twenty-two consecutive patients with spinal fractures (eight with spinal cord injuries) were studied. All patients were immobilized in bed for 6 weeks after trauma. The occurrence of deep venous thrombosis (DVT) was detected by the 125I-labeled fibrinogen test and confirmed by venography. F VIII:C, F VIII:Ag, and AT III activities were determined 2, 6, and 10 to 12 days after trauma. All paralyzed patients (n = 8) developed DVT and two of them had pulmonary embolism within 5 days after trauma. F VIII:Ag and F VIII:C disproportionally increased and the values of F VIII:Ag/F VIII:C ratio above 2 predicted DVT. AT III remained normal during the whole immobilization time and the values of DVT(+) and DVT(-) groups were comparable.
对22例连续性脊柱骨折患者（其中8例伴有脊髓损伤）进行了研究。所有患者在创伤后均卧床制动6周。通过125I标记的纤维蛋白原试验检测深静脉血栓形成（DVT）的发生情况，并通过静脉造影进行确诊。在创伤后2天、6天以及10至12天测定F VIII:C、F VIII:Ag和抗凝血酶III（AT III）活性。所有瘫痪患者（n = 8）均发生了DVT，其中2例在创伤后5天内出现了肺栓塞。F VIII:Ag和F VIII:C不成比例地升高，F VIII:Ag/F VIII:C比值大于2可预测DVT。在整个制动期间，AT III保持正常，DVT阳性组和阴性组的值具有可比性。
