Shrestha R D, Fujimoto S, Igarashi K, Ohta M, Kokubun M, Endoh F, Okui K
Gan No Rinsho. 1987 Feb;33(2):179-83.
To evaluate the antitumor efficacy of polyamine antimetabolites such as methylglyoxal-bis-guanylhydrazone (MGBG), ethylglyoxal-bis-guanylhydrazone (EGBG), and alpha-difluoromethylornithine (DFMO), the combined therapies of polyamine antimetabolites with a polyamine-free diet were studied. The combination of EGBG plus DFMO or MGBG plus DFMO showed a marked suppression of tumor growth with a polyamine-free diet; and, when compared, EGBG was slightly superior to MGBG. The inhibition of DNA biosynthesis was also parallel to the above-mentioned results. Furthermore, from an analysis for polyamine levels in tumor tissues, it was confirmed that the polyamine depletion can be maintained by polyamine antimetabolites in combination with a polyamine-free diet in vivo. Moreover, as EGBG has lesser side effects than MGBG, EGBG might be more suitable for clinical use.
为评估多胺抗代谢物如甲基乙二醛双脒腙（MGBG）、乙基乙二醛双脒腙（EGBG）和α-二氟甲基鸟氨酸（DFMO）的抗肿瘤疗效，研究了多胺抗代谢物与无多胺饮食的联合疗法。EGBG加DFMO或MGBG加DFMO的组合在无多胺饮食时显示出对肿瘤生长的显著抑制；并且，相比之下，EGBG略优于MGBG。DNA生物合成的抑制也与上述结果平行。此外，通过对肿瘤组织中多胺水平的分析，证实多胺抗代谢物与无多胺饮食联合在体内可维持多胺耗竭。而且，由于EGBG的副作用比MGBG小，EGBG可能更适合临床使用。
