A review on cellulose nanocrystals as promising biocompounds for the synthesis of nanocomposite hydrogels.

Hydrogels are hydrophilic cross-linked polymer networks formed via the simple reaction of one or more monomers with the ability to retain a significant extent of water. Owing to an increased demand for environmentally friendly, biodegradable, and biocompatible products, cellulose nanocrystals (CNCs) with high hydrophilicity have emerged as a promising sustainable material for the formation of hydrogels. The cytocompatibility, swellability, and non-toxicity make CNC hydrogels of great interest in biomedical, biosensing, and wastewater treatment applications. There has been a considerable progress in the research of CNC hydrogels, as the number of scientific publications has exponentially increased (>600%) in the last five years. In this paper, recent progress in CNC hydrogels with particular emphasis on design, materials, and fabrication techniques to control hydrogel architecture, and advanced applications are discussed.