IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy.
Department of Neurology, University Hospital Würzburg, Würzburg, Germany.
Pediatr Neurol. 2019 Nov;100:80-86. doi: 10.1016/j.pediatrneurol.2019.03.005. Epub 2019 Mar 16.
We aim to describe and psychometrically validate the Rett Syndrome Motor Evaluation Scale, a 25-item ordinal scale examining (loco-)motor function across six sections: standing, sitting, transitions, walking, running, and walking up or downstairs.
We illustrate the process of item construction and validation, report findings and normative data obtained on a standardization sample of 60 patients with Rett syndrome. We investigate the validity and reliability of the scale and illustrate its psychometric properties using modern multivariate techniques of data analysis.
Sixty patients with Rett syndrome were included (all female; mean age 12.45 (S.D. 8.75) years). The multidimensional latent structure of the scale was supported by the results of the confirmatory factor analysis. Rett Syndrome Motor Evaluation Scale showed strong internal consistency reliability as well as excellent inter-rater agreement. The Rett Syndrome Motor Evaluation Scale scores were not predicted by age, but were associated with disease severity, degree of spasticity, and hand dysfunction. We also identified three latent classes with different degrees of impairment.
Rett Syndrome Motor Evaluation Scale is a new, valid, and reliable scale that can be introduced in clinical practice when assessing (loco-)motor function in Rett syndrome.
本研究旨在描述和心理测量验证 Rett 综合征运动评估量表，这是一个 25 项的等级量表，涵盖六个部分：站立、坐、转换、行走、跑步和上下楼梯，评估（局部）运动功能。
我们展示了项目构建和验证的过程，报告了对 60 名雷特综合征患者标准化样本的研究结果和获得的规范数据。我们通过现代多元数据分析技术，调查了该量表的有效性和可靠性，并说明了其心理测量特性。
纳入 60 名雷特综合征患者（均为女性；平均年龄 12.45（标准差 8.75）岁）。验证性因子分析的结果支持该量表的多维潜在结构。Rett 综合征运动评估量表具有很强的内部一致性信度和极好的评分者间一致性。Rett 综合征运动评估量表评分不受年龄影响，但与疾病严重程度、痉挛程度和手功能障碍有关。我们还确定了三个具有不同损伤程度的潜在类别。
Rett 综合征运动评估量表是一种新的、有效的、可靠的量表，可以在临床实践中引入，用于评估雷特综合征的（局部）运动功能。
