• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一级创伤中心脂肪栓塞综合征患者的临床特征与管理

Clinical characteristics and management of patients with fat embolism syndrome in level I Apex Trauma Centre.

作者信息

Aggarwal Richa, Banerjee Arnab, Soni Kapil Dev, Kumar Atin, Trikha Anjan

机构信息

Critical and Intensive Care, JPNATC, All India Institute of Medical Sciences, New Delhi, India.

Department of Plastic Surgery, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Chin J Traumatol. 2019 Jun;22(3):172-176. doi: 10.1016/j.cjtee.2019.01.007. Epub 2019 Mar 14.

DOI:10.1016/j.cjtee.2019.01.007
PMID:31047796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6543189/
Abstract

PURPOSE

Fat embolism syndrome (FES) is systemic manifestation of fat emboli in the circulation seen mostly after long bone fractures. FES is considered a lethal complication of trauma. There are various case reports and series describing FES. Here we describe the clinical characteristics, management in ICU and outcome of these patients in level I trauma center in a span of 6 months.

METHODS

In this prospective study, analysis of all the patients with FES admitted in our polytrauma intensive care unit (ICU) of level I trauma center over a period of 6 months (from August 2017 to January 2018) was done. Demographic data, clinical features, management in ICU and outcome were analyzed.

RESULTS

We admitted 10 cases of FES. The mean age of patients was 31.2 years. The mean duration from time of injury to onset of symptoms was 56 h. All patients presented with hypoxemia and petechiae but central nervous system symptoms were present in 70% of patients. The mean duration of mechanical ventilation was 11.7 days and the mean length of ICU stay was 14.7 days. There was excellent recovery among patients with no neurological deficit.

CONCLUSION

FES is considered a lethal complication of trauma but timely management can result in favorable outcome. FES can occur even after fixation of the fracture. Hypoxia is the most common and earliest feature of FES followed by CNS manifestations. Any patient presenting with such symptoms should raise the suspicion of FES and mandate early ICU referral.

摘要

目的

脂肪栓塞综合征(FES)是循环系统中脂肪栓子的全身性表现,多见于长骨骨折后。FES被认为是创伤的一种致命并发症。有各种关于FES的病例报告和系列研究。在此,我们描述了在一家一级创伤中心6个月内这些患者的临床特征、在重症监护病房(ICU)的治疗及预后情况。

方法

在这项前瞻性研究中,对我们一级创伤中心的多创伤重症监护病房(ICU)在6个月期间(从2017年8月至2018年1月)收治的所有FES患者进行了分析。分析了人口统计学数据、临床特征、在ICU的治疗及预后情况。

结果

我们收治了10例FES患者。患者的平均年龄为31.2岁。从受伤到症状出现的平均时长为56小时。所有患者均出现低氧血症和瘀点,但70%的患者有中枢神经系统症状。机械通气的平均时长为11.7天,ICU住院的平均时长为14.7天。无神经功能缺损的患者恢复良好。

结论

FES被认为是创伤的一种致命并发症,但及时治疗可带来良好预后。即使在骨折固定后也可能发生FES。低氧是FES最常见和最早出现的特征,其次是中枢神经系统表现。任何出现此类症状的患者都应怀疑FES,并要求尽早转诊至ICU。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/da5f61f4561c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/8bb3e3878590/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/7aa87d4fd15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/43db98a281a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/5257c16660c8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/da5f61f4561c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/8bb3e3878590/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/7aa87d4fd15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/43db98a281a3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/5257c16660c8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70c/6543189/da5f61f4561c/gr5.jpg

相似文献

1
Clinical characteristics and management of patients with fat embolism syndrome in level I Apex Trauma Centre.一级创伤中心脂肪栓塞综合征患者的临床特征与管理
Chin J Traumatol. 2019 Jun;22(3):172-176. doi: 10.1016/j.cjtee.2019.01.007. Epub 2019 Mar 14.
2
Multisystemic involvement of post-traumatic fat embolism at a Pediatric Trauma Center: a clinical series and literature review.一家儿科创伤中心创伤后脂肪栓塞的多系统累及:临床系列病例及文献综述
Eur J Pediatr. 2023 Apr;182(4):1811-1821. doi: 10.1007/s00431-023-04869-6. Epub 2023 Feb 15.
3
Risk Factors of Fat Embolism Syndrome After Trauma: A Nested Case-Control Study With the Use of a Nationwide Trauma Registry in Japan.创伤后脂肪栓塞综合征的危险因素:一项使用日本全国创伤登记处的巢式病例对照研究。
Chest. 2021 Mar;159(3):1064-1071. doi: 10.1016/j.chest.2020.09.268. Epub 2020 Oct 13.
4
Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study.白细胞介素-6 作为脂肪栓塞综合征早期标志物的作用:一项临床研究。
Clin Orthop Relat Res. 2013 Jul;471(7):2340-6. doi: 10.1007/s11999-013-2869-y. Epub 2013 Feb 20.
5
Two variants of fat embolism syndrome evolving in a young patient with multiple fractures.一名患有多处骨折的年轻患者出现了脂肪栓塞综合征的两种变体。
BMJ Case Rep. 2013 Apr 9;2013:bcr2013008631. doi: 10.1136/bcr-2013-008631.
6
The use of corticosteroid for the prophylaxis of fat embolism syndrome in patients with long bone fracture.皮质类固醇在长骨骨折患者中预防脂肪栓塞综合征的应用。
Rev Col Bras Cir. 2013 Sep-Oct;40(5):423-6. doi: 10.1590/s0100-69912013000500013.
7
[Post-traumatic systemic fat embolism syndrome. Retrospective autopsy study].[创伤后系统性脂肪栓塞综合征。回顾性尸检研究]
Srp Arh Celok Lek. 2000 Jan-Feb;128(1-2):24-8.
8
Fat embolism syndrome: Experience from an Australian trauma centre.脂肪栓塞综合征:来自澳大利亚一家创伤中心的经验。
Int J Orthop Trauma Nurs. 2020 Feb;36:100746. doi: 10.1016/j.ijotn.2019.100746. Epub 2019 Oct 31.
9
Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis.皮质类固醇激素能否降低长骨骨折患者发生脂肪栓塞综合征的风险?一项荟萃分析。
Can J Surg. 2009 Oct;52(5):386-93.
10
Fat embolism syndrome in long bone fracture--clinical experience in a tertiary referral center in Taiwan.长骨骨折脂肪栓塞综合征-台湾一家三级转诊中心的临床经验。
J Chin Med Assoc. 2010 Aug;73(8):407-10. doi: 10.1016/S1726-4901(10)70088-5.

引用本文的文献

1
Fat embolism: the hidden murder for trauma patients!脂肪栓塞:创伤患者的隐形杀手!
Rev Col Bras Cir. 2024 May 6;51:e20243690. doi: 10.1590/0100-6991e-20243690-en. eCollection 2024.
2
Epidemiology and risk factors for fat embolism in isolated lower extremity long bone fractures.孤立下肢长骨骨折中脂肪栓塞的流行病学和危险因素。
Eur J Trauma Emerg Surg. 2024 Aug;50(4):1775-1781. doi: 10.1007/s00068-024-02516-9. Epub 2024 Apr 17.
3
High Dependency Unit Admissions among Patients with Lower Extremity Long Bone Fracture Visiting the Department of Orthopaedics in a Tertiary Care Centre.

本文引用的文献

1
Fat Embolism Syndrome: Lung Computed Tomography Findings in 18 Patients.脂肪栓塞综合征:18例患者的肺部计算机断层扫描结果
J Comput Assist Tomogr. 2016 May-Jun;40(3):335-42. doi: 10.1097/RCT.0000000000000376.
2
Fat embolism syndrome: State-of-the-art review focused on pulmonary imaging findings.脂肪栓塞综合征:聚焦于肺部影像学表现的最新综述
Respir Med. 2016 Apr;113:93-100. doi: 10.1016/j.rmed.2016.01.018. Epub 2016 Feb 1.
3
Fat embolism syndrome.脂肪栓塞综合征
骨科患者下肢长骨骨折入住三级医疗中心高依赖病房的情况。
JNMA J Nepal Med Assoc. 2024 Feb 24;62(270):121-124. doi: 10.31729/jnma.8430.
4
Occurrence of Numerous Cerebral White Matter Hyperintensities in Trauma Patients With Cerebral Fat Embolism: A Systematic Review and Report of Two Cases.脑脂肪栓塞创伤患者中大量脑白质高信号的发生:一项系统评价及两例报告
Cureus. 2023 Sep 18;15(9):e45450. doi: 10.7759/cureus.45450. eCollection 2023 Sep.
5
Multisystemic involvement of post-traumatic fat embolism at a Pediatric Trauma Center: a clinical series and literature review.一家儿科创伤中心创伤后脂肪栓塞的多系统累及:临床系列病例及文献综述
Eur J Pediatr. 2023 Apr;182(4):1811-1821. doi: 10.1007/s00431-023-04869-6. Epub 2023 Feb 15.
6
A Rare Case of Fat Embolism Syndrome Masquerading as COVID-19 Pneumonia.一例伪装成新冠肺炎肺炎的脂肪栓塞综合征罕见病例。
Cureus. 2022 Mar 22;14(3):e23384. doi: 10.7759/cureus.23384. eCollection 2022 Mar.
7
Fat embolism syndrome in blunt trauma patients with extremity fractures.钝性创伤致四肢骨折患者的脂肪栓塞综合征
J Orthop. 2020 Sep 6;21:475-480. doi: 10.1016/j.jor.2020.08.040. eCollection 2020 Sep-Oct.
8
Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports.创伤性骨折后脑脂肪栓塞:文献回顾分析及已发表病例报告。
Scand J Trauma Resusc Emerg Med. 2021 Mar 12;29(1):47. doi: 10.1186/s13049-021-00861-x.
9
Increase in optic nerve sheath diameter predicts early cerebral involvement in fat embolism syndrome.视神经鞘直径增大可预测脂肪栓塞综合征早期脑受累。
Chin J Traumatol. 2021 May;24(3):180-182. doi: 10.1016/j.cjtee.2021.02.004. Epub 2021 Feb 9.
10
Incidence and related factors of hypoxia associated with elderly femoral neck fractures in the emergency department setting.急诊科老年股骨颈骨折相关低氧血症的发生率及相关因素
Acute Med Surg. 2020 Dec 20;7(1):e618. doi: 10.1002/ams2.618. eCollection 2020 Jan-Dec.
Lung India. 2013 Jan;30(1):47-53. doi: 10.4103/0970-2113.106133.
4
Analyzing fat embolism syndrome in trauma patients at AIIMS Apex Trauma Center, New Delhi, India.对印度新德里全印医学科学研究所顶级创伤中心的创伤患者脂肪栓塞综合征进行分析。
J Emerg Trauma Shock. 2011 Jul;4(3):337-41. doi: 10.4103/0974-2700.83859.
5
Fat embolism.脂肪栓塞
Anesthesiol Clin. 2009 Sep;27(3):533-50, table of contents. doi: 10.1016/j.anclin.2009.07.018.
6
Fat embolism syndrome.脂肪栓塞综合征
Am J Med Sci. 2008 Dec;336(6):472-7. doi: 10.1097/MAJ.0b013e318172f5d2.
7
Fat embolism syndrome: clinical examination is still the preferable diagnostic method.脂肪栓塞综合征:临床检查仍是首选的诊断方法。
Chest. 2003 Apr;123(4):982-3. doi: 10.1378/chest.123.4.982.
8
Fat embolism syndrome. A 10-year review.脂肪栓塞综合征。十年回顾。
Arch Surg. 1997 Apr;132(4):435-9. doi: 10.1001/archsurg.1997.01430280109019.
9
Unusual forms of pulmonary embolism.肺栓塞的不寻常形式。
Clin Chest Med. 1994 Sep;15(3):561-80.
10
Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients.用皮质类固醇预防脂肪栓塞。对高危患者的前瞻性研究。
Ann Intern Med. 1983 Oct;99(4):438-43. doi: 10.7326/0003-4819-99-4-438.