Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Portugal.
Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Portugal.
Neurosci Lett. 2019 Jul 27;706:1-6. doi: 10.1016/j.neulet.2019.04.056. Epub 2019 Apr 29.
The lack of consistent findings in the research field of psychopathy unveils the heterogeneity of this personality structure and, therefore, a dissociation of its phenotypic components is a promising venue to conciliate paradoxical results. The current study aims to assess the dissociable effects of psychopathic traits on N2 and P3 modulation, while analyzing the stability of some endophenotypic processes across development. A sample of adolescents (n = 33) and adults (n = 31) completed, respectively, the Youth Psychopathy Inventory and the Triarchic Psychopathy Measure and performed the same Go/No-Go task during an EEG recording. For adolescents, the unemotionality and remorselessness subdimensions of the callous-unemotional (CU) factor predicted, respectively, reduced N2 and P3 amplitudes. This suggests impaired inhibitory control in both subdimensions of the broad CU factor. However, the callousness subdimension of the CU factor predicted increased N2 amplitude. This pattern of findings was also observed for meanness in adults, which leads to the hypothesis that callousness traits may be a specific precursor of meanness.
在精神病态学的研究领域中，缺乏一致性的发现揭示了这种人格结构的异质性，因此，对其表型成分进行分离是调和矛盾结果的一个有前途的途径。本研究旨在评估精神病态特征对 N2 和 P3 调制的可分离影响，同时分析一些表型过程在整个发展过程中的稳定性。一组青少年（n=33）和成年人（n=31）分别完成了青少年精神病态检查表和三因素精神病态量表，并在 EEG 记录期间执行了相同的 Go/No-Go 任务。对于青少年来说，冷酷无情和无情无义这两个精神变态的亚维度分别预测了 N2 和 P3 振幅的降低。这表明在广泛的冷酷无情因素的两个亚维度中，抑制控制受损。然而，冷酷无情因素的冷酷亚维度预测了 N2 振幅的增加。在成年人中也观察到了类似的刻薄行为模式，这导致了一个假设，即冷酷无情的特征可能是刻薄行为的一个特定前兆。
