Astoin M, Canton-Poincelot B, Masson A, Russo-Marie F
Pathol Biol (Paris). 1987 Feb;35(2 Pt 2):244-6.
The biological effects of two vasodilatory drugs, SIN-1 (the active metabolite of molsidomine) and nitroglycerin were analysed in the arterial endothelium and vascular muscle. Both drugs induce the secretion of prostacyclin in endothelial cells in culture, but this secretion is short-lived and occurs for high doses of the two drugs (above 10(-5)M). These same drugs induce a dose-dependent relaxing effect on the smooth muscle contracted either by norepinephrine or 5-hydroxytryptamine with an ED50 of 5.10(-7)M. This relaxation is neither secondary to an endothelium-derived product nor to a cyclooxygenase or lipoxygenase-derived product.
分析了两种血管舒张药物SIN-1（吗多明的活性代谢产物）和硝酸甘油在动脉内皮和血管平滑肌中的生物学效应。两种药物均能诱导培养的内皮细胞分泌前列环素，但这种分泌是短暂的，且在两种药物的高剂量（高于10^(-5)M）时才会发生。这些相同的药物对由去甲肾上腺素或5-羟色胺收缩的平滑肌产生剂量依赖性舒张作用，半数有效剂量（ED50）为5×10^(-7)M。这种舒张作用既不是内皮衍生产物介导的，也不是环氧化酶或脂氧合酶衍生产物介导的。
