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迈向消除麻疹的进展 - 欧洲区域,2009-2018 年。

Progress Toward Measles Elimination - European Region, 2009-2018.

出版信息

MMWR Morb Mortal Wkly Rep. 2019 May 3;68(17):396-401. doi: 10.15585/mmwr.mm6817a4.

Abstract

In 2010, all 53 countries* in the World Health Organization (WHO) European Region (EUR) reconfirmed their commitment to eliminating measles and rubella and congenital rubella syndrome (1); this goal was included as a priority in the European Vaccine Action Plan 2015-2020 (2). The WHO-recommended elimination strategies in EUR include 1) achieving and maintaining ≥95% coverage with 2 doses of measles-containing vaccine (MCV) through routine immunization services; 2) providing measles and rubella vaccination opportunities, including supplementary immunization activities (SIAs), to populations susceptible to measles or rubella; 3) strengthening surveillance by conducting case investigations and confirming suspected cases and outbreaks with laboratory results; and 4) improving the availability and use of evidence for the benefits and risks associated with vaccination (3). This report updates a previous report (4) and describes progress toward measles elimination in EUR during 2009-2018. During 2009-2017, estimated regional coverage with the first MCV dose (MCV1) was 93%-95%, and coverage with the second dose (MCV2) increased from 73% to 90%. In 2017, 30 (57%) countries achieved ≥95% MCV1 coverage, and 15 (28%) achieved ≥95% coverage with both doses. During 2009-2018, >16 million persons were vaccinated during SIAs in 13 (24%) countries. Measles incidence declined to 5.8 per 1 million population in 2016, but increased to 89.5 in 2018, because of large outbreaks in several EUR countries. To achieve measles elimination in EUR, measures are needed to strengthen immunization programs by ensuring ≥95% 2-dose MCV coverage in every district of each country, offering supplemental measles vaccination to susceptible adults, maintaining high-quality surveillance for rapid case detection and confirmation, and ensuring effective outbreak preparedness and response.

摘要

2010 年,世界卫生组织(世卫组织)欧洲区域(EUR)的所有 53 个国家*再次确认承诺消除麻疹和风疹以及先天性风疹综合征(1);这一目标被纳入 2015-2020 年《欧洲疫苗行动计划》(2)的优先事项。世卫组织在 EUR 推荐的消除策略包括 1)通过常规免疫服务,实现并维持麻疹风疹联合疫苗(MCV)2 剂次接种率≥95%;2)向易感染麻疹或风疹的人群提供麻疹和风疹疫苗接种机会,包括补充免疫活动(SIAs);3)通过开展病例调查和用实验室结果确认疑似病例和暴发来加强监测;以及 4)改善与疫苗接种相关的益处和风险的证据的可获取性和使用(3)。本报告更新了之前的报告(4),并介绍了 2009-2018 年 EUR 消除麻疹的进展情况。在 2009-2017 年期间,区域内第一剂麻疹风疹联合疫苗(MCV1)估计接种率为 93%-95%,第二剂(MCV2)接种率从 73%增加到 90%。2017 年,有 30 个(57%)国家实现了 MCV1 覆盖率≥95%,有 15 个(28%)国家实现了两剂次的覆盖率≥95%。在 2009-2018 年期间,有 13 个(24%)国家在补充免疫活动期间对超过 1600 万人进行了疫苗接种。2016 年麻疹发病率降至每百万人 5.8 例,但由于几个 EUR 国家的大规模暴发,2018 年上升至 89.5 例。为了在 EUR 实现消除麻疹的目标,需要采取措施加强免疫规划,确保每个国家的每个区 2 剂次 MCV 覆盖率均≥95%,为易感染的成年人提供补充麻疹疫苗接种,保持高质量的监测以快速发现和确认病例,并确保有效的暴发准备和应对。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac82/6541314/1b447ee95cf2/mm6817a4-F.jpg

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