[Influence of molsidomine, SIN-1 and nitroglycerin on the metabolism of prostaglandins by human fibroblasts].

In human skin fibroblasts, exposed during 24 h to molsidomine and SIN-1, the functional status of prostaglandin synthesis is altered in so far, that the bradykinin stimulation of thromboxane is inhibited whereas the production of other PG's is not different from control. Exposure to GTN induces no such inhibition of thromboxane. During the first 5 minutes of exposure, both SIN-1 and GTN stimulate the synthesis of 6-oxo-PGF1-alpha and of PGE2 but not of TXB2. Whereas SIN-1 shows a cumulative stimulatory effect with bradykinin, GTN lacks this effect. According to the findings of this human cell model, we conclude that the sydnonimines, like GTN, stimulate, at least under the present conditions, the formation of vasodilatory prostaglandins and, in addition, that they inhibit irreversibly the formation of proaggregatory thromboxane.