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特发性血小板减少性紫癜中模拟黑色素瘤的脉络膜上腔出血

Suprachoroidal Hemorrhage Simulating Melanoma in Idiopathic Thrombocytopenic Purpura.

作者信息

Honig Stephanie E, Srinivasan Archana, Shields Carol L

机构信息

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Ocul Oncol Pathol. 2019 Apr;5(3):162-166. doi: 10.1159/000490390. Epub 2018 Oct 11.

Abstract

BACKGROUND

We report a case of suprachoroidal hemorrhage simulating choroidal melanoma in a patient with idiopathic thrombocytopenic purpura (ITP).

METHODS

Case report.

RESULTS

A 79-year-old white male with a history of lung adenocarcinoma, ITP, and mild anemia noted blurred vision with photopsia and floaters in the right eye (OD) that worsened over 2 months. He was found to have a pigmented choroidal mass and was referred for evaluation of possible choroidal melanoma. Visual acuity was 20/30 in the affected right eye and 20/25 in the left eye (OS). There was mild vitreous hemorrhage and 2 pigmented peripheral choroidal tumors in the temporal and nasal fundus OD. B-scan ultrasonography confirmed 2 acoustically hollow tumors, and transillumination demonstrated no shadowing. Optical coherence tomography over the lesions revealed choroidal elevation with suprachoroidal scalloped surface. Fluorescein and indocyanine green angiography revealed normal choroidal fluorescence and cyanescence with no "double circulation" of melanoma and no dye blockage, suggesting a suprachoroidal location. These findings were suggestive of suprachoroidal hemorrhage rather than melanoma. The patient was managed conservatively, and the hemorrhages demonstrated spontaneous resolution.

CONCLUSION

Ocular manifestations of ITP are uncommon. Rarely, spontaneous suprachoroidal hemorrhage simulating melanoma can occur. A thorough clinical evaluation with multimodal imaging is critical to establishing the appropriate diagnosis.

摘要

背景

我们报告一例特发性血小板减少性紫癜(ITP)患者发生的模拟脉络膜黑色素瘤的脉络膜上腔出血。

方法

病例报告。

结果

一名79岁白人男性,有肺腺癌、ITP和轻度贫血病史,右眼出现视力模糊、闪光感和飞蚊症,症状在2个月内逐渐加重。检查发现其有一个色素性脉络膜肿物,遂转诊以评估是否可能为脉络膜黑色素瘤。患眼(右眼)视力为20/30,左眼视力为20/25。右眼颞侧和鼻侧眼底有轻度玻璃体出血和2个色素性周边脉络膜肿瘤。B超检查证实有2个无回声肿物,透照检查未显示阴影。病变部位的光学相干断层扫描显示脉络膜隆起,脉络膜上腔表面呈扇形。荧光素和吲哚菁绿血管造影显示脉络膜荧光和青灰色正常,无黑色素瘤的“双循环”且无染料渗漏,提示为脉络膜上腔病变。这些发现提示为脉络膜上腔出血而非黑色素瘤。患者接受保守治疗,出血自行消退。

结论

ITP的眼部表现并不常见。罕见情况下,可发生模拟黑色素瘤的自发性脉络膜上腔出血。通过多模式影像学进行全面的临床评估对于做出正确诊断至关重要。

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本文引用的文献

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Clinical updates in adult immune thrombocytopenia.成人免疫性血小板减少症的临床进展
Blood. 2017 May 25;129(21):2829-2835. doi: 10.1182/blood-2017-03-754119. Epub 2017 Apr 17.
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Advances in Diagnosis and Treatments for Immune Thrombocytopenia.免疫性血小板减少症的诊断与治疗进展
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Choroidal hemorrhage simulating choroidal melanoma.模拟脉络膜黑色素瘤的脉络膜出血
Retina. 2013 Sep;33(8):1726-8. doi: 10.1097/IAE.0b013e31828dac9d.
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