Vincenzi Colombina, Marisaldi Benedetta, Tosti Antonella, Patel Brijeshkumar
Private Hospital Nigrisoli, Bologna, Italy.
Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.
Skin Appendage Disord. 2019 Apr;5(3):146-151. doi: 10.1159/000493200. Epub 2018 Oct 10.
Female pattern hair loss (FPHL) is increasing ly common and often presents with hair shedding. Spec tral. DNC-N® contains anti-inflammatory actives and hair growth promoters.
To assess the efficacy and tolerability of Spectral DNC-N® (DS Laboratories, Inc.) in women with early FPHL and excessive shedding.
Forty-nine patients were treated with Spectral DNC-N®, applied twice daily for 3 months; 28 patients were included in the 3-month treatment extension. Efficacy assessments included the degree of hair shedding using the validated hair shedding visual scale, hair mass index (HMI), and photographic evaluation.
There was a statistically significant decrease in hair shedding and a corresponding increase in HMI by month 3, which was maintained through month 6. The mean investigator-assessed hair shedding score decreased from 3.5 to 2.0 and the hair mass increased from 75.8 to 84.3 mm>sup<2>/supsup<2>/sup< by month 3 (both < 0.01 compared with baseline). By month 6, the hair shedding score was reduced to 1.6 and the hair mass was maintained. Most patients (75%) showed an increase in global hair density.
Spectral. DNC-N® significantly reduced hair shedding, with a corresponding increase in hair mass and density. These effects were already evident after 3 months' treatment and further improved in those patients who continued treatment to month 6. Tolerability was good and patient satisfaction levels were high.
女性型脱发（FPHL）越来越常见，且常伴有脱发症状。Spectral DNC-N®含有抗炎活性成分和头发生长促进剂。
评估Spectral DNC-N®（DS Laboratories公司）对早期FPHL且脱发过多的女性的疗效和耐受性。
49例患者接受Spectral DNC-N®治疗，每天涂抹两次，持续3个月；28例患者纳入为期3个月的治疗延长阶段。疗效评估包括使用经过验证的脱发视觉量表评估脱发程度、头发质量指数（HMI）以及照片评估。
到第3个月时，脱发量有统计学意义的显著减少，HMI相应增加，且这种情况持续到第6个月。到第3个月时，研究人员评估的平均脱发评分从3.5降至2.0，头发质量从75.8增加至84.3mm²/cm²（与基线相比均P<0.01）。到第6个月时，脱发评分降至1.6，头发质量保持稳定。大多数患者（75%）的整体头发密度增加。
Spectral DNC-N®显著减少脱发，同时头发质量和密度相应增加。这些效果在治疗3个月后已很明显，继续治疗至6个月的患者情况进一步改善。耐受性良好，患者满意度较高。
