Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University (NanjingTech), Nanjing 211816, China.
Chem Commun (Camb). 2019 May 25;55(42):5934-5937. doi: 10.1039/c9cc02224d. Epub 2019 May 3.
A small-molecule photoacoustic probe based on cyanine dyes was developed by taking advantage of the nucleophilic substitution reaction of HS with chlorine. The probe demonstrated specific response to HS with ratiometric photoacoustic signals in the NIR region, which enabled real-time, accurate, high-resolution imaging of endogenous HS in vivo.
一种基于花菁染料的小分子光声探针，利用 HS 与氯的亲核取代反应开发而成。该探针对 HS 具有特异性响应，在近红外区域产生比率型光声信号，从而能够实时、准确、高分辨率地对体内内源性 HS 进行成像。
