肛门直肠细胞学检查作为检测HIV阳性男性肛门上皮内瘤变的筛查工具。
Anal-rectal cytology as a screening tool for the detection of anal intraepithelial neoplasia in HIV-positive men.
作者信息
Selvaggi Suzanne M
机构信息
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, Wisconsin.
出版信息
J Am Soc Cytopathol. 2014 May-Jun;3(3):151-155. doi: 10.1016/j.jasc.2014.01.004. Epub 2014 Jan 17.
INTRODUCTION
Use of anal-rectal cytology is on the rise as a screening tool for the detection of anal squamous lesions in human immunodeficiency virus (HIV)-positive individuals. The purpose of this 5-year retrospective study was to determine the utility of routine anal-rectal screening for the detection of squamous lesions in HIV-positive patients with histology correlation.
MATERIALS AND METHODS
From January 1, 2008 through December 31, 2012, 448 anal-rectal Papanicolaou tests were performed on HIV-positive men, of which 133 were referred for high-resolution anoscopy.
RESULTS
Of the 448 cases, 184 (41%) were classified as atypical squamous cells of undetermined significance or above, of which 133 (72%) had histologic correlation. Nine (7%) were negative, 64 (48%) were anal intraepithelial neoplasia (AIN) 1, 36 (27%) were AIN 2, 21 (16%) were AIN 3, and 3 (2%) were squamous cell carcinoma.
CONCLUSIONS
The results of this study support the use of anal-rectal cytology as a screening tool in the detection of anal intraepithelial neoplasia, particularly in high-risk populations.
引言
作为一种筛查工具，肛门直肠细胞学检查在检测人类免疫缺陷病毒（HIV）阳性个体的肛门鳞状病变中的应用正在增加。这项为期5年的回顾性研究的目的是确定常规肛门直肠筛查在检测HIV阳性患者鳞状病变并与组织学进行相关性分析方面的效用。
材料与方法
2008年1月1日至2012年12月31日，对HIV阳性男性进行了448次肛门直肠巴氏试验，其中133例被转诊进行高分辨率肛门镜检查。
结果
在448例病例中，184例（41%）被分类为意义不明确的非典型鳞状细胞或更高级别，其中133例（72%）有组织学相关性。9例（7%）为阴性，64例（48%）为肛门上皮内瘤变（AIN）1级，36例（27%）为AIN 2级，21例（16%）为AIN 3级，3例（2%）为鳞状细胞癌。
结论
本研究结果支持将肛门直肠细胞学检查作为检测肛门上皮内瘤变的筛查工具，尤其是在高危人群中。
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