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Local anesthetic systemic toxicity: proposed mechanisms for lipid resuscitation and methods of prevention.

作者信息

Oda Yutaka

机构信息

Department of Anesthesiology, Osaka City Juso Hospital, 2-12-27, Nonaka-kita, Yodogawa-ku, Osaka, 532-0034, Japan.

出版信息

J Anesth. 2019 Oct;33(5):569-571. doi: 10.1007/s00540-019-02648-y. Epub 2019 May 3.

DOI:10.1007/s00540-019-02648-y
PMID:31053930
Abstract
摘要

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1
Practical guide for the management of systemic toxicity caused by local anesthetics.局部麻醉剂引起的全身毒性管理实用指南。
J Anesth. 2019 Feb;33(1):1-8. doi: 10.1007/s00540-018-2542-4. Epub 2018 Nov 11.
2
Adding dextran to local anesthetic enhances analgesia.在局部麻醉剂中添加右旋糖酐可增强镇痛效果。
J Anesth. 2019 Feb;33(1):163. doi: 10.1007/s00540-018-2573-x. Epub 2018 Nov 7.
3
The history and progress of local anesthesia: multiple approaches to elongate the action.局部麻醉的历史和进展：延长作用的多种方法。
J Anesth. 2018 Aug;32(4):632-636. doi: 10.1007/s00540-018-2514-8. Epub 2018 May 31.
4
The Mechanisms Underlying Lipid Resuscitation Therapy.脂质复苏治疗的作用机制。
Reg Anesth Pain Med. 2018 Feb;43(2):138-149. doi: 10.1097/AAP.0000000000000719.
5
Bupivacaine Indirectly Potentiates Glutamate-induced Intracellular Calcium Signaling in Rat Hippocampal Neurons by Impairing Mitochondrial Function in Cocultured Astrocytes.布比卡因通过损害共培养星形胶质细胞中线粒体功能间接增强谷氨酸诱导的大鼠海马神经元细胞内钙离子信号转导。
Anesthesiology. 2018 Mar;128(3):539-554. doi: 10.1097/ALN.0000000000002003.
6
Local anesthetics systemic toxicity association with exparel (bupivacaine liposome)- a pharmacovigilance evaluation.局部麻醉药全身毒性与 Exparel（布比卡因脂质体）的关联：药物警戒评估。
Expert Opin Drug Saf. 2018 Jun;17(6):581-587. doi: 10.1080/14740338.2017.1335304. Epub 2017 Jun 5.
7
Possible utility of contrast-enhanced ultrasonography for detecting spread of local anesthetic in nerve block.超声造影在检测局部麻醉药在神经阻滞中的扩散方面的潜在效用。
J Anesth. 2017 Jun;31(3):365-373. doi: 10.1007/s00540-017-2347-x. Epub 2017 Apr 3.
8
Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study.英脱利匹特对志愿者耐受的罗哌卡因或左旋布比卡因剂量的影响：一项临床和药代动力学研究。
Anesthesiology. 2016 Sep;125(3):474-83. doi: 10.1097/ALN.0000000000001230.
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Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion.布比卡因诱导的心脏毒性中的胰岛素信号传导：恢复过程中的敏化作用及脂质乳剂的增强作用
Anesthesiology. 2016 Feb;124(2):428-42. doi: 10.1097/ALN.0000000000000974.
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Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.脂质乳剂复苏：心脏药理学毒性的剂量依赖性恢复需要心脏兴奋作用。
Anesthesiology. 2014 Apr;120(4):915-25. doi: 10.1097/ALN.0000000000000142.