Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.
Department of Endocrinology and Diabetes, The Royal Children's Hospital, Parkville, VIC, Australia.
Metabolomics. 2019 May 3;15(5):75. doi: 10.1007/s11306-019-1537-y.
Specific patterns of metabolomic profiles relating to cardiometabolic disease are associated with increased weight in adults. In youth with obesity, metabolomic data are sparse and associations with adiposity measures unknown.
Primary, to determine associations between adiposity measures and metabolomic profiles with increased cardiometabolic risks in youth with obesity. Secondary, to stratify associations by sex and puberty.
Participants were from COBRA (Childhood Overweight BioRepository of Australia; a paediatric cohort with obesity). Adiposity measures (BMI, BMI z-score, %truncal and %whole body fat, waist circumference and waist/height ratio), puberty staging and NMR metabolomic profiles from serum were assessed. Statistics included multivariate analysis (principal component analysis, PCA) and multiple linear regression models with false discovery rate adjustment.
214 participants had metabolomic profiles analyzed, mean age 11.9 years (SD ± 3.1), mean BMI z-score 2.49 (SD ± 0.24), 53% females. Unsupervised PCA identified no separable clusters of individuals. Positive associations included BMI z-score and phenylalanine, total body fat % and lipids in medium HDL, and waist circumference and tyrosine; negative associations included total body fat % and the ratio of docosahexaenoic acid/total fatty acids and histidine. Stratifying by sex and puberty, patterns of associations with BMI z-score in post-pubertal males included positive associations with lipid-, cholesterol- and triglyceride-content in VLDL lipoproteins; total fatty acids; total triglycerides; isoleucine, leucine and glycoprotein acetyls.
In a paediatric cohort with obesity, increased adiposity measures, especially in post-pubertal males, were associated with distinct patterns in metabolomic profiles.
与代谢相关的特定模式与成年人的心血管代谢疾病相关，且与肥胖有关。在肥胖的年轻人中，代谢组学数据很少，与肥胖指标的关联未知。
主要目的是确定肥胖青少年的肥胖指标与代谢组学特征与心血管代谢风险增加之间的关联。次要目的是按性别和青春期进行分层。
参与者来自 COBRA（澳大利亚儿童超重生物库；一个肥胖的儿科队列）。评估了肥胖指标（BMI、BMI z 分数、%躯干和%全身脂肪、腰围和腰高比）、青春期分期和血清 NMR 代谢组学特征。统计方法包括多元分析（主成分分析，PCA）和具有错误发现率调整的多元线性回归模型。
214 名参与者的代谢组学特征进行了分析，平均年龄为 11.9 岁（标准差 ± 3.1），平均 BMI z 分数为 2.49（标准差 ± 0.24），女性占 53%。非监督 PCA 未识别出个体的可分离聚类。阳性关联包括 BMI z 分数和苯丙氨酸、全身脂肪%和中高密度脂蛋白中的脂质，以及腰围和酪氨酸；负相关包括全身脂肪%和二十二碳六烯酸/总脂肪酸和组氨酸的比例。按性别和青春期分层，BMI z 分数与后青春期男性的关联模式包括与 VLDL 脂蛋白中的脂质、胆固醇和甘油三酯含量的正相关；总脂肪酸；总甘油三酯；异亮氨酸、亮氨酸和糖蛋白乙酰基。
在肥胖的儿科队列中，增加的肥胖指标，尤其是在后青春期男性中，与代谢组学特征中的独特模式有关。
