反对冯·雷克林霍增氏神经纤维瘤病与19号染色体标记物连锁的证据。

Evidence against linkage of von Recklinghausen neurofibromatosis and chromosome 19 markers.

作者信息

Huson S M, Meredith A L, Sarfarazi M, Shaw D J, Brook D, Compston D A, Harper P S

出版信息

Ann N Y Acad Sci. 1986;486:349-53. doi: 10.1111/j.1749-6632.1986.tb48088.x.

DOI:10.1111/j.1749-6632.1986.tb48088.x

Abstract

In this paper we report the study of the segregation of three chromosome 19 markers known to be linked to myotonic dystrophy in nine families with von Recklinghausen neurofibromatosis. Clear evidence against linkage was found for all three markers excluding the von Recklinghausen neurofibromatosis gene from the myotonic dystrophy region of chromosome 19.

摘要

在本文中，我们报告了对9个患有冯·雷克林霍增氏神经纤维瘤病家族中已知与强直性肌营养不良相关的3个19号染色体标记物分离情况的研究。发现所有这3个标记物均无连锁的明确证据，从而将冯·雷克林霍增氏神经纤维瘤病基因排除在19号染色体强直性肌营养不良区域之外。