Tanahashi T, Matsumura Y, Yoshimoto J, Tsushima T, Obama T, Akagi T, Ochi J, Hara M, Saegusa M, Ohmori H
Gan To Kagaku Ryoho. 1987 Apr;14(4):1156-9.
Interferon (IFN) was used in the treatment of superficial bladder tumors. Interferon (IFN-beta, IFN-gamma) was instilled into the bladder at dosages ranging from 16 billion to 36 billion U IFN per 30 ml physiological saline. The IFN was instilled into the bladder once a day or twice a day for 10 to 20 days. In this trial, ten patients with superficial bladder tumors were treated at Okayama City Hospital, and of these, 1 CR, 3 PR, 2 MR and 4 NC were obtained. There were no signs of either irritable bladder or general side effects. IFN (especially IFN-beta) is considered a useful drug for superficial bladder tumors in intravesical chemotherapy.
干扰素（IFN）用于浅表性膀胱肿瘤的治疗。将干扰素（β-干扰素、γ-干扰素）以每30毫升生理盐水中含160亿至360亿单位干扰素的剂量注入膀胱。干扰素每天注入膀胱一次或两次，持续10至20天。在该试验中，冈山城市医院对10例浅表性膀胱肿瘤患者进行了治疗，其中1例完全缓解（CR）、3例部分缓解（PR）、2例病情稳定（MR）和4例无变化（NC）。未出现膀胱刺激征或全身副作用。干扰素（尤其是β-干扰素）被认为是膀胱内化疗治疗浅表性膀胱肿瘤的一种有用药物。
